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Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation

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Engelbrechtsen, L ; Gybel-Brask, D ; Mahendran, Y ; Crusell, M ; Hansen, Tue H ; Schnurr, T M ; Hogdall, E ; Skibsted, L ; Hansen, Torben ; Vestergaard, H. / Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation. In: Scientific Reports. 2018 ; Vol. 8, No. 1. pp. 8376.

Bibtex

@article{37e44605b9464ef5902ba9fc9a84e309,
title = "Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation",
abstract = "Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10-6 percentage points/allele/day (p = 2.0 × 10-4), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20-25 or 25-32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease.",
author = "L Engelbrechtsen and D Gybel-Brask and Y Mahendran and M Crusell and Hansen, {Tue H} and Schnurr, {T M} and E Hogdall and L Skibsted and Torben Hansen and H Vestergaard",
year = "2018",
month = "5",
day = "30",
doi = "10.1038/s41598-018-26752-3",
language = "English",
volume = "8",
pages = "8376",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation

AU - Engelbrechtsen, L

AU - Gybel-Brask, D

AU - Mahendran, Y

AU - Crusell, M

AU - Hansen, Tue H

AU - Schnurr, T M

AU - Hogdall, E

AU - Skibsted, L

AU - Hansen, Torben

AU - Vestergaard, H

PY - 2018/5/30

Y1 - 2018/5/30

N2 - Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10-6 percentage points/allele/day (p = 2.0 × 10-4), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20-25 or 25-32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease.

AB - Fetal intrauterine growth is influenced by complex interactions between the maternal genes, environment and fetal genes. The aim of this study was to assess the effect of GWAS-identified genetic variants associated with birth weight on intrauterine fetal growth in 665 children. Fetal growth was estimated by two-dimensional ultrasound scans at 20, 25 and 32 weeks of gestation and growth trajectories were modeled using mixed linear regression. A genetic risk score (GRS) of birth weight-raising variants was associated with intrauterine growth showing an attenuating effect on the unconditional daily reduction in proportional weight gain of 8.92 × 10-6 percentage points/allele/day (p = 2.0 × 10-4), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20-25 or 25-32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease.

U2 - 10.1038/s41598-018-26752-3

DO - 10.1038/s41598-018-26752-3

M3 - Journal article

VL - 8

SP - 8376

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -

ID: 54442774