Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Biomarkers of Whole-Grain and Cereal-Fiber Intake in Human Studies: A Systematic Review of the Available Evidence and Perspectives

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Impact of Meal Timing and Chronotype on Food Reward and Appetite Control in Young Adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition

    Research output: Contribution to journalReviewResearchpeer-review

  3. Perinatal Whole Blood Zinc Status and Cytokines, Adipokines, and Other Immune Response Proteins

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Copenhagen Primary Care Laboratory Pregnancy (CopPreg) database

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment

    Research output: Contribution to journalReviewResearchpeer-review

  3. Adolescent wine consumption is inversely associated with long-term weight gain: results from follow-up of 20 or 22 years

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

High whole-grain consumption is related to better health outcomes. The specific physiological effect of these compounds is still unrevealed, partly because the accurate estimation of the intake of whole grains from dietary assessments is difficult and prone to bias, due to the complexity of the estimation of the intake by the consumer. A biomarker of whole-grain intake and type of whole-grain intake would be useful for quantifying the exposure to whole-grain intake. In this review, we aim to review the evidence on the potential biomarkers for whole-grain intake in the literature. We conducted a systematic search in Medline, Embase, Web of Science, and the Cochrane database. In total, 39 papers met the inclusion criteria following the PRISMA guidelines and were included. The relative validity, responsiveness, and reproducibility of these markers were assessed for short-, medium-, and long-term exposure as important criteria for the potential use of these biomarkers from a clinical and research perspective. We found three major groups of biomarkers: (1) alkylresorcinol, as well as its homologs and metabolites, assessed in plasma, adipose tissue biopsies, erythrocyte membranes, and urine; (2) avenacosides, assessed in urine samples; and (3) benzoxazinoid-derived phenylacetamide sulfates, assessed in blood and urine samples. The reviewed biomarkers may be used for improved assessment of associations between whole-grain intake and health outcomes.

Original languageEnglish
JournalNutrients
Volume11
Issue number12
ISSN2072-6643
DOIs
Publication statusPublished - 6 Dec 2019

ID: 58861456