Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania

Stéphanie Boström, Samad Ibitokou, Mayke Oesterholt, Christentze Schmiegelow, Jan-Olov Persson, Daniel Thomas Minja, John Peter Andrea Lusingu, Martha Lemnge, Nadine Fievet, Philippe Deloron, Adrian J F Luty, Marita Troye-Blomberg

    27 Citations (Scopus)


    In pregnant women, Plasmodium falciparum infections are an important cause of maternal morbidity as well as fetal and neonatal mortality. Erythrocytes infected by these malaria-causing parasites accumulate through adhesive interactions in placental intervillous spaces, thus evading detection in peripheral blood smears. Sequestered infected erythrocytes induce inflammation, offering the possibility of detecting inflammatory mediators in peripheral blood that could act as biomarkers of placental infection. In a longitudinal, prospective study in Tanzania, we quantified a range of different cytokines, chemokines and angiogenic factors in peripheral plasma samples, taken on multiple sequential occasions during pregnancy up to and including delivery, from P. falciparum-infected women and matched uninfected controls. The results show that during healthy, uninfected pregnancies the levels of most of the panel of molecules we measured were largely unchanged except at delivery. In women with P. falciparum, however, both comparative and longitudinal assessments consistently showed that the levels of IL-10 and IP-10 increased significantly whilst that of RANTES decreased significantly, regardless of gestational age at the time the infection was detected. ROC curve analysis indicated that a combination of increased IL-10 and IP-10 levels and decreased RANTES levels might be predictive of P. falciparum infections. In conclusion, our data suggest that host biomarkers in peripheral blood may represent useful diagnostic markers of P. falciparum infection during pregnancy, but placental histology results would need to be included to verify these findings.
    Original languageEnglish
    JournalP L o S One
    Issue number11
    Pages (from-to)e48763
    Publication statusPublished - 2012


    Dive into the research topics of 'Biomarkers of Plasmodium falciparum Infection during Pregnancy in Women Living in Northeastern Tanzania'. Together they form a unique fingerprint.

    Cite this