Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Biomarkers for Alzheimer's Disease in Saliva: A Systematic Review

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Physical activity enhances metabolic fitness independently of cardiorespiratory fitness in marathon runners

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Serum markers of liver fibrosis: combining the BIPED classification and the neo-epitope approach in the development of new biomarkers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ageing as a risk factor for neurodegenerative disease

    Research output: Contribution to journalReviewResearchpeer-review

  2. Automatically computed rating scales from MRI for patients with cognitive disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Ventriculoperitoneal Shunt Complications in the European Idiopathic Normal Pressure Hydrocephalus Multicenter Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: The histopathological changes of Alzheimer's disease (AD) are detectable decades prior to its clinical expression. However, there is a need for an early, inexpensive, noninvasive diagnostic biomarker to detect specific Alzheimer pathology. Recently developed neuroimaging biomarkers show promising results, but these methods are expensive and cause radiation. Furthermore, the analysis of cerebrospinal fluid (CSF) biomarkers requires an invasive lumbar puncture. Saliva is an easily obtained body fluid, and a stable saliva biomarker would therefore be a promising candidate for a future method for diagnosing AD. The purpose of this systematic review was to investigate studies of biomarkers in saliva samples for the diagnosis of AD.

Methods: The included articles were identified through a literature search in PubMed and Google Scholar for all articles until November 1st, 2018, and furthermore, all reference lists of included articles were reviewed by hand. We included articles written in English investigating saliva from patients with AD and a control group.

Results: A total of 65 studies were identified, whereof 16 studies met the inclusion criteria and were included in the systematic review. A plethora of different biomarkers were investigated, and ten out of the sixteen studies showed a statistical significance in biomarkers between patients with AD and healthy, elderly controls, among these biomarkers for specific AD pathology (amyloid beta 1-42 (Aβ42) and tau).

Conclusion: Aβ42 and tau seem to be worthy candidates for future salivary biomarkers for AD, but other biomarkers such as lactoferrin and selected metabolites also have potential. More studies must be carried out with larger sample sizes and a standardization of the sampling and processing method. Factors such as diurnal variation, AD patients' decreased ability of oral self-care, and salivary flowrates must be taken into consideration.

Original languageEnglish
JournalDisease Markers
Volume2019
Pages (from-to)4761054
ISSN0278-0240
DOIs
Publication statusPublished - 2019

ID: 58035495