Biological variations in plasma VEGF and VEGFR-1 may compromise their biomarker value in colorectal cancer

Mads Nordahl Svendsen, Nils Brünner, Ib J Christensen, Henriette Ytting, Camilla Bentsen, Anne Fog Lomholt, Hans J Nielsen

6 Citations (Scopus)

Abstract

Vascular Endothelial Growth Factor (VEGF) plays a prominent role in tumor angiogenesis and plasma VEGF concentration may carry prognostic information in colorectal cancer. The VEGF receptor 1 (VEGFR-1) is a regulatory receptor which is shredded into plasma of patients with colorectal cancer. For both molecules, large biological variation and lack of standardization of assay procedures are major challenges.
Original languageEnglish
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume70
Issue number7
Pages (from-to)503-11
Number of pages9
ISSN0036-5513
DOIs
Publication statusPublished - 1 Nov 2010

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