Biological response modifiers and their potential use in the treatment of inflammatory skin diseases

Louise S Villadsen, Lone Skov, Ole Baadsgaard

8 Citations (Scopus)

Abstract

In recent years, a more detailed understanding of the pathogenesis of several inflammatory skin diseases, combined with the developments within biotechnology, has made it possible to design more selective response modifiers. Biological response modifiers hold the potential for greater effectiveness and fewer side-effects than the current systemic therapies now used for severe psoriasis, contact dermatitis and atopic dermatitis. In the pathogenesis of inflammatory skin diseases, the immune system plays a pivotal role, and this is where biological response modifiers such as monoclonal antibodies, recombinant cytokines, or fusion proteins may be effective. Several biological response modifiers have already shown positive results in phase II/III clinical trials in skin diseases, and many new biological response modifiers are in progress.

Original languageEnglish
JournalExperimental Dermatology
Volume12
Issue number1
Pages (from-to)1-10
Number of pages10
ISSN0906-6705
Publication statusPublished - Feb 2003

Keywords

  • Animals
  • Antibodies, Monoclonal
  • Cytokines
  • Dermatitis
  • Dermatitis, Atopic
  • Dermatitis, Contact
  • Humans
  • Immunologic Factors
  • Psoriasis
  • Recombinant Fusion Proteins
  • Recombinant Proteins

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