Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Bio-equivalent doses of recombinant HCG and recombinant LH during ovarian stimulation result in similar oestradiol output: a randomized controlled study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Meditation and mindfulness reduce perceived stress in women with recurrent pregnancy loss: a randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Stress and depression among women and men who have experienced recurrent pregnancy loss: focusing on both sexes

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Empathetic application of machine learning may address appropriate utilization of ART

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The reproductive microbiome - clinical practice recommendations for fertility specialists

    Research output: Contribution to journalReviewResearchpeer-review

  1. Proteome of fluid from human ovarian small antral follicles reveals insights in folliculogenesis and oocyte maturation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Umbilical cord blood-derived platelet-rich plasma: a clinically acceptable substitute for fetal bovine serum?

    Research output: Contribution to journalEditorialResearchpeer-review

  4. Parental Acceptance Rate of Testicular Tissue Cryopreservation in Danish Boys with Cryptorchidism

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Biological and Clinical Rationale for Androgen Priming in Ovarian Stimulation

    Research output: Contribution to journalReviewResearchpeer-review

  • Birgit Alsbjerg
  • Helle Olesen Elbaek
  • Rita Jakubcionyte Laursen
  • Betina Boel Povlsen
  • Thor Haahr
  • Claus Yding Andersen
  • Peter Humaidan
View graph of relations

In nature, HCG is secreted by the implanting embryo from peri-implantation and onwards. In contrast, LH is mandatory for steroidogenesis and follicular development during the follicular phase, working in synergy with FSH. Moreover, LH is mandatory for the function of the corpus luteum. Although LH and HCG bind to the same receptor, significant molecular, structural and functional differences exist, inducing differences in bioactivity. This randomized controlled study compared the effect of recombinant FSH stimulation combined with daily either micro-dose recombinant HCG or recombinant LH supplementation in a 1:1 bioactivity ratio from day 1 of stimulation in a long gonadotrophin releasing hormone agonist down regulation protocol. A total of 100 patients from a public clinic completed the study. The primary end-point was the oestradiol level on the day of ovulation trigger and the median oestradiol level in the HCG supplemented group was 8662 pmol/l versus 9203 pmol/l in the recombinant LH supplemented group; therefore, no significant difference was found. Moreover, no differences were observed in the number of oocytes retrieved or in the live birth rate. We conclude that recombinant HCG and recombinant LH are equally effective in boosting oestradiol synthesis during ovarian stimulation when used in a 1:1 bioactivity ratio.

Original languageEnglish
JournalReproductive BioMedicine Online
Volume35
Issue number2
Pages (from-to)232-238
Number of pages7
ISSN1472-6483
DOIs
Publication statusPublished - Aug 2017

    Research areas

  • Journal Article

ID: 51647775