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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

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  1. The tolerance of anisometropia

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  2. Low physical activity and higher use of screen devices are associated with myopia at the age of 16-17 years in the CCC2000 Eye Study

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  3. Loss of retinal tension and permanent decrease in retinal function: a new porcine model of rhegmatogenous retinal detachment

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  4. Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes

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  1. Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

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  2. Tumour control probability after Ruthenium-106 brachytherapy for choroidal melanomas

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  3. Estimating narrow-sense heritability using family data from admixed populations

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  4. The tolerance of anisometropia

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  5. Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

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Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

Original languageEnglish
JournalActa Ophthalmologica
Volume95
Issue number5
Pages (from-to)439-445
Number of pages7
ISSN1755-375X
DOIs
Publication statusPublished - Aug 2017

    Research areas

  • Aged, Cell Proliferation, Ciliary Body, Humans, Male, Melanocytes, Paraneoplastic Syndromes, Tomography, Optical Coherence, Uveal Diseases, Case Reports, Journal Article, Review

ID: 52209321