Bilateral Diabetic Papillopathy and Metabolic Control

Christoffer Ostri; Henrik Lund-Andersen; Birgit Sander; Ditte Hvidt-Nielsen; Michael Larsen

doi:10.1016/j.ophtha.2010.03.006

Bilateral Diabetic Papillopathy and Metabolic Control

Christoffer Ostri, Henrik Lund-Andersen, Birgit Sander, Ditte Hvidt-Nielsen, Michael Larsen

Department of Ophthalmology

35 Citations (Scopus)

Abstract

OBJECTIVE: The pathogenesis of diabetic papillopathy largely is unknown, but case reports suggest that it may follow rapidly improved metabolic control. The present study was designed to investigate this hypothesis. DESIGN: Retrospective case-control study. PARTICIPANTS: Two thousand sixty-six patients with type 1 diabetes. METHODS: Review of clinical, photographic, and clinical chemistry records from a large diabetology and ophthalmology unit between 2001 and 2008. MAIN OUTCOME MEASURES: Simultaneous, bilateral diabetic papillopathy. RESULTS: The mean follow-up was 4.9 years. During 10 020 patient-years of observation, bilateral diabetic papillopathy developed in 5 patients. During the year preceding this incident, all 5 patients had experienced a decrease in glycosylated hemoglobin A(1c) (HbA(1C)) at a maximum rate of -2.5 (mean) percentage points per quarter year, which was significantly different from the changes in HbA(1C) observed in the remainder of the study population (P

Original language	English
Journal	Ophthalmology
Volume	117
Issue number	11
Pages (from-to)	214-217
Number of pages	4
ISSN	0161-6420
DOIs	https://doi.org/10.1016/j.ophtha.2010.03.006
Publication status	Published - 15 Jun 2010

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10.1016/j.ophtha.2010.03.006

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title = "Bilateral Diabetic Papillopathy and Metabolic Control",

abstract = "OBJECTIVE: The pathogenesis of diabetic papillopathy largely is unknown, but case reports suggest that it may follow rapidly improved metabolic control. The present study was designed to investigate this hypothesis. DESIGN: Retrospective case-control study. PARTICIPANTS: Two thousand sixty-six patients with type 1 diabetes. METHODS: Review of clinical, photographic, and clinical chemistry records from a large diabetology and ophthalmology unit between 2001 and 2008. MAIN OUTCOME MEASURES: Simultaneous, bilateral diabetic papillopathy. RESULTS: The mean follow-up was 4.9 years. During 10 020 patient-years of observation, bilateral diabetic papillopathy developed in 5 patients. During the year preceding this incident, all 5 patients had experienced a decrease in glycosylated hemoglobin A(1c) (HbA(1C)) at a maximum rate of -2.5 (mean) percentage points per quarter year, which was significantly different from the changes in HbA(1C) observed in the remainder of the study population (P",

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T1 - Bilateral Diabetic Papillopathy and Metabolic Control

AU - Ostri, Christoffer

AU - Lund-Andersen, Henrik

AU - Sander, Birgit

AU - Hvidt-Nielsen, Ditte

AU - Larsen, Michael

PY - 2010/6/15

Y1 - 2010/6/15

N2 - OBJECTIVE: The pathogenesis of diabetic papillopathy largely is unknown, but case reports suggest that it may follow rapidly improved metabolic control. The present study was designed to investigate this hypothesis. DESIGN: Retrospective case-control study. PARTICIPANTS: Two thousand sixty-six patients with type 1 diabetes. METHODS: Review of clinical, photographic, and clinical chemistry records from a large diabetology and ophthalmology unit between 2001 and 2008. MAIN OUTCOME MEASURES: Simultaneous, bilateral diabetic papillopathy. RESULTS: The mean follow-up was 4.9 years. During 10 020 patient-years of observation, bilateral diabetic papillopathy developed in 5 patients. During the year preceding this incident, all 5 patients had experienced a decrease in glycosylated hemoglobin A(1c) (HbA(1C)) at a maximum rate of -2.5 (mean) percentage points per quarter year, which was significantly different from the changes in HbA(1C) observed in the remainder of the study population (P

AB - OBJECTIVE: The pathogenesis of diabetic papillopathy largely is unknown, but case reports suggest that it may follow rapidly improved metabolic control. The present study was designed to investigate this hypothesis. DESIGN: Retrospective case-control study. PARTICIPANTS: Two thousand sixty-six patients with type 1 diabetes. METHODS: Review of clinical, photographic, and clinical chemistry records from a large diabetology and ophthalmology unit between 2001 and 2008. MAIN OUTCOME MEASURES: Simultaneous, bilateral diabetic papillopathy. RESULTS: The mean follow-up was 4.9 years. During 10 020 patient-years of observation, bilateral diabetic papillopathy developed in 5 patients. During the year preceding this incident, all 5 patients had experienced a decrease in glycosylated hemoglobin A(1c) (HbA(1C)) at a maximum rate of -2.5 (mean) percentage points per quarter year, which was significantly different from the changes in HbA(1C) observed in the remainder of the study population (P

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U2 - 10.1016/j.ophtha.2010.03.006

DO - 10.1016/j.ophtha.2010.03.006

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C2 - 20557939

SN - 0161-6420

VL - 117

SP - 214

EP - 217

JO - Ophthalmology

JF - Ophthalmology

IS - 11

ER -

Bilateral Diabetic Papillopathy and Metabolic Control

Abstract

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