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Bihormonal control of blood glucose in people with type 1 diabetes

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This paper presents a bihormonal artificial pancreas (AP) for people with type 1 diabetes (T1D) designed to provide a safe blood glucose control with minimal use of glucagon. The control algorithm uses insulin as well as glucagon to prevent hyper- and hypoglycemia. We employ a novel prediction-based activation of glucagon administration. The control algorithm consists of a Kalman filter, an insulin infusion model predictive controller (MPC), a proportional-derivative (PD) controller for glucagon infusion, and a meal time insulin bolus calculator. The PD controller is activated if the Kalman filter predicts hypoglycemia. Predictions utilize an ARMAX model describing glucose-insulin and glucose-glucagon dynamics. The model parameters are estimated from basic patient-specific data. A continuous glucose monitor provides feedback. We test the control algorithm using a simulation model with time-varying parameters available for 3 patients. We consider a simulation scenario where meals are estimated correctly as well as overestimated by 30%. The simulation results demonstrate that during normal operation, the controller only needs insulin and does not need glucagon. During unexpected events, such as insulin overdose due to an overestimated meal, the control algorithm uses glucagon efficiently to avoid severe hypoglycemia.

Original languageEnglish
Title of host publication2015 European Control Conference, ECC 2015
Number of pages6
PublisherInstitute of Electrical and Electronics Engineers Inc.
Publication date16 Nov 2015
Pages25-30
Article number7330520
ISBN (Electronic)9783952426937
DOIs
Publication statusPublished - 16 Nov 2015
EventEuropean Control Conference, ECC 2015 - Linz, Austria
Duration: 15 Jul 201517 Jul 2015

Conference

ConferenceEuropean Control Conference, ECC 2015
LandAustria
ByLinz
Periode15/07/201517/07/2015

Event

European Control Conference, ECC 2015

15/07/201517/07/2015

Linz, Austria

Event: Conference

ID: 52336494