Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

Jørgen Vestbo; Julie Anne Anderson; Peter Mark Anthony Calverley; Bartolomé Celli; Gary Thomas Ferguson; Christine Jenkins; Julie Carol Yates; Paul Wyatt Jones

doi:10.1111/j.1752-699X.2010.00198.x

Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

Jørgen Vestbo, Julie Anne Anderson, Peter Mark Anthony Calverley, Bartolomé Celli, Gary Thomas Ferguson, Christine Jenkins, Julie Carol Yates, Paul Wyatt Jones

75 Citations (Scopus)

Abstract

Randomised controlled trials (RCTs) are considered the least biased method for evaluating drug efficacy and several large long-term RCTs in chronic obstructive pulmonary disease have been published. These usually include drugs with symptomatic benefits and have significant withdrawal rates.

Original language	English
Journal	Clinical Respiratory Journal
Volume	5
Issue number	1
Pages (from-to)	44-9
Number of pages	6
ISSN	1752-6981
DOIs	https://doi.org/10.1111/j.1752-699X.2010.00198.x
Publication status	Published - 2011

Keywords

Albuterol
Androstadienes
Bias (Epidemiology)
Bronchodilator Agents
Drug Combinations
Humans
Observation
Patient Dropouts
Placebos
Proportional Hazards Models
Pulmonary Disease, Chronic Obstructive
Randomized Controlled Trials as Topic

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10.1111/j.1752-699X.2010.00198.x

Cite this

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abstract = "Randomised controlled trials (RCTs) are considered the least biased method for evaluating drug efficacy and several large long-term RCTs in chronic obstructive pulmonary disease have been published. These usually include drugs with symptomatic benefits and have significant withdrawal rates.",

keywords = "Albuterol, Androstadienes, Bias (Epidemiology), Bronchodilator Agents, Drug Combinations, Humans, Observation, Patient Dropouts, Placebos, Proportional Hazards Models, Pulmonary Disease, Chronic Obstructive, Randomized Controlled Trials as Topic",

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AU - Vestbo, Jørgen

AU - Anderson, Julie Anne

AU - Calverley, Peter Mark Anthony

AU - Celli, Bartolomé

AU - Ferguson, Gary Thomas

AU - Jenkins, Christine

AU - Yates, Julie Carol

AU - Jones, Paul Wyatt

PY - 2011

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KW - Bias (Epidemiology)

KW - Bronchodilator Agents

KW - Drug Combinations

KW - Humans

KW - Observation

KW - Patient Dropouts

KW - Placebos

KW - Proportional Hazards Models

KW - Pulmonary Disease, Chronic Obstructive

KW - Randomized Controlled Trials as Topic

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JO - Clinical Respiratory Journal

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ER -

Bias due to withdrawal in long-term randomised trials in COPD: evidence from the TORCH study

Abstract

Keywords

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