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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus

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Oral administration of glucose stimulates insulin secretion to a greater extent than does glucose administered as an isoglycaemic intravenous glucose infusion. This phenomenon is called the incretin effect and is caused by the two incretin hormones GIP and GLP-1. In patients with type 2 diabetes, the incretin effect is impaired. The mechanisms of the impaired incretin effect have been found to involve reduced secretion of GLP-1 and a severely impaired effect of GIP. It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors.
Translated title of the contribution[Effect of incretin hormones GIP and GLP-1 for the pathogenesis of type 2 diabetes mellitus]
Original languageDanish
JournalUgeskrift for Laeger
Volume169
Issue number22
Pages (from-to)2101-5
Number of pages5
Publication statusPublished - 28 May 2007

ID: 32267830