Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy

B Als-Nielsen; L L Kjaergard; C Gluud

doi:10.1002/14651858.CD002798

Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy

B Als-Nielsen, L L Kjaergard, C Gluud

Copenhagen Trial Unit

40 Citations (Scopus)

Abstract

The pathogenesis of hepatic encephalopathy is unknown. It has been suggested that liver failure leads to the accumulation of substances that bind to a receptor-complex in the brain resulting in neural inhibition which may progress to coma. Several trials have assessed benzodiazepine receptor antagonists for hepatic encephalopathy, but the results are conflicting.

Original language	English
Journal	Cochrane Database of Systematic Reviews
Issue number	4
Pages (from-to)	CD002798
ISSN	1469-493X
DOIs	https://doi.org/10.1002/14651858.CD002798
Publication status	Published - 2001

Keywords

Acute Disease
Antidotes
Chronic Disease
Flumazenil
GABA Modulators
GABA-A Receptor Antagonists
Hepatic Encephalopathy
Humans
Randomized Controlled Trials as Topic

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10.1002/14651858.CD002798

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abstract = "The pathogenesis of hepatic encephalopathy is unknown. It has been suggested that liver failure leads to the accumulation of substances that bind to a receptor-complex in the brain resulting in neural inhibition which may progress to coma. Several trials have assessed benzodiazepine receptor antagonists for hepatic encephalopathy, but the results are conflicting.",

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AU - Als-Nielsen, B

AU - Kjaergard, L L

AU - Gluud, C

PY - 2001

Y1 - 2001

N2 - The pathogenesis of hepatic encephalopathy is unknown. It has been suggested that liver failure leads to the accumulation of substances that bind to a receptor-complex in the brain resulting in neural inhibition which may progress to coma. Several trials have assessed benzodiazepine receptor antagonists for hepatic encephalopathy, but the results are conflicting.

AB - The pathogenesis of hepatic encephalopathy is unknown. It has been suggested that liver failure leads to the accumulation of substances that bind to a receptor-complex in the brain resulting in neural inhibition which may progress to coma. Several trials have assessed benzodiazepine receptor antagonists for hepatic encephalopathy, but the results are conflicting.

KW - Acute Disease

KW - Antidotes

KW - Chronic Disease

KW - Flumazenil

KW - GABA Modulators

KW - GABA-A Receptor Antagonists

KW - Hepatic Encephalopathy

KW - Humans

KW - Randomized Controlled Trials as Topic

UR - https://www.scopus.com/pages/publications/0035225784

U2 - 10.1002/14651858.CD002798

DO - 10.1002/14651858.CD002798

M3 - Journal article

C2 - 11687160

SN - 1469-493X

SP - CD002798

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

IS - 4

ER -

Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy

Abstract

Keywords

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