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Beginnings: a reflection on the history of gastrointestinal endocrinology

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@article{03660f0ca7314676b259d3d4015ec350,
title = "Beginnings: a reflection on the history of gastrointestinal endocrinology",
abstract = "The gut is the largest endocrine organ in the body. Gut hormones share some characteristics: Their structure groups hormones into families, each of which originate from a single gene. A hormone gene is often expressed in multiple peptides due to tandem genes, alternative splicing or differentiated posttranslational processing. By these mechanisms, more than 100 different hormonally active peptides are produced in the gastrointestinal tract. In addition, gut hormones are widely expressed outside the gut. The different cell types often express different products of the same gene and release the peptides in different ways. Consequently, the same peptide may act as a hormone, a local growth factor, or a neurotransmitter. This new biology suggests that gastrointestinal hormones should be conceived as intercellular messengers of major general impact. The following short review is a vignette on steps in the history of gastrointestinal endocrinology from classic studies of digestive juice secretion over peptide chemistry, immunochemistry, and molecular genetics to modern receptor pharmacology and drug development. From shadowy beginnings, gastrointestinal endocrinology has emerged as a central discipline in the understanding of multicellular life and its diseases.",
keywords = "Animals, Cell Membrane, Drug Therapy, Endocrine Glands, Endocrinology, Gastrointestinal Hormones, Gastrointestinal Tract, Genes, Regulator, History, 20th Century, History, 21st Century, Humans, Neuroendocrine Tumors, Peptide Hormones, Phylogeny, Radioimmunoassay",
author = "Rehfeld, {Jens F}",
note = "Copyright {\circledC} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
doi = "10.1016/j.regpep.2012.05.087",
language = "English",
volume = "177 Suppl",
pages = "S1--5",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Beginnings

T2 - a reflection on the history of gastrointestinal endocrinology

AU - Rehfeld, Jens F

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012

Y1 - 2012

N2 - The gut is the largest endocrine organ in the body. Gut hormones share some characteristics: Their structure groups hormones into families, each of which originate from a single gene. A hormone gene is often expressed in multiple peptides due to tandem genes, alternative splicing or differentiated posttranslational processing. By these mechanisms, more than 100 different hormonally active peptides are produced in the gastrointestinal tract. In addition, gut hormones are widely expressed outside the gut. The different cell types often express different products of the same gene and release the peptides in different ways. Consequently, the same peptide may act as a hormone, a local growth factor, or a neurotransmitter. This new biology suggests that gastrointestinal hormones should be conceived as intercellular messengers of major general impact. The following short review is a vignette on steps in the history of gastrointestinal endocrinology from classic studies of digestive juice secretion over peptide chemistry, immunochemistry, and molecular genetics to modern receptor pharmacology and drug development. From shadowy beginnings, gastrointestinal endocrinology has emerged as a central discipline in the understanding of multicellular life and its diseases.

AB - The gut is the largest endocrine organ in the body. Gut hormones share some characteristics: Their structure groups hormones into families, each of which originate from a single gene. A hormone gene is often expressed in multiple peptides due to tandem genes, alternative splicing or differentiated posttranslational processing. By these mechanisms, more than 100 different hormonally active peptides are produced in the gastrointestinal tract. In addition, gut hormones are widely expressed outside the gut. The different cell types often express different products of the same gene and release the peptides in different ways. Consequently, the same peptide may act as a hormone, a local growth factor, or a neurotransmitter. This new biology suggests that gastrointestinal hormones should be conceived as intercellular messengers of major general impact. The following short review is a vignette on steps in the history of gastrointestinal endocrinology from classic studies of digestive juice secretion over peptide chemistry, immunochemistry, and molecular genetics to modern receptor pharmacology and drug development. From shadowy beginnings, gastrointestinal endocrinology has emerged as a central discipline in the understanding of multicellular life and its diseases.

KW - Animals

KW - Cell Membrane

KW - Drug Therapy

KW - Endocrine Glands

KW - Endocrinology

KW - Gastrointestinal Hormones

KW - Gastrointestinal Tract

KW - Genes, Regulator

KW - History, 20th Century

KW - History, 21st Century

KW - Humans

KW - Neuroendocrine Tumors

KW - Peptide Hormones

KW - Phylogeny

KW - Radioimmunoassay

U2 - 10.1016/j.regpep.2012.05.087

DO - 10.1016/j.regpep.2012.05.087

M3 - Journal article

VL - 177 Suppl

SP - S1-5

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

ER -

ID: 36789807