BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania

Daniel Faurholt-Jepsen; Nyagosya Range; George Amani Praygod; Kidola Jeremiah; Maria Faurholt-Jepsen; Martine G Aabye; Harleen M S Grewal; John Changalucha; Daniel Rinse Witte; Aase B Andersen; Henrik Friis

doi:10.1136/thoraxjnl-2012-201971

BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania

Daniel Faurholt-Jepsen, Nyagosya Range, George Amani Praygod, Kidola Jeremiah, Maria Faurholt-Jepsen, Martine G Aabye, Harleen M S Grewal, John Changalucha, Daniel Rinse Witte, Aase B Andersen, Henrik Friis

Department of Clinical Research

21 Citations (Scopus)

Abstract

While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.

Original language	English
Journal	Thorax
Volume	68
Issue number	3
Pages (from-to)	288-289
Number of pages	2
ISSN	0040-6376
DOIs	https://doi.org/10.1136/thoraxjnl-2012-201971
Publication status	Published - 2013

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10.1136/thoraxjnl-2012-201971

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@article{a45d074ae052464eaa3286615d5ae495,

title = "BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania",

abstract = "While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95\% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.",

author = "Daniel Faurholt-Jepsen and Nyagosya Range and Praygod, \{George Amani\} and Kidola Jeremiah and Maria Faurholt-Jepsen and Aabye, \{Martine G\} and Grewal, \{Harleen M S\} and John Changalucha and Witte, \{Daniel Rinse\} and Andersen, \{Aase B\} and Henrik Friis",

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doi = "10.1136/thoraxjnl-2012-201971",

language = "English",

volume = "68",

pages = "288--289",

journal = "Thorax",

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T1 - BCG protects against tuberculosis irrespective of HIV status

T2 - a matched case-control study in Mwanza, Tanzania

AU - Faurholt-Jepsen, Daniel

AU - Range, Nyagosya

AU - Praygod, George Amani

AU - Jeremiah, Kidola

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine G

AU - Grewal, Harleen M S

AU - Changalucha, John

AU - Witte, Daniel Rinse

AU - Andersen, Aase B

AU - Friis, Henrik

PY - 2013

Y1 - 2013

N2 - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.

AB - While BCG vaccine protects against severe tuberculosis (TB) in children, its effect against adult TB is questionable. Furthermore, it is not known if HIV co-infection modifies the effect of BCG. Among 352 pairs of Tanzanian TB cases and matched controls, the BCG scar was associated with a reduced risk of TB (OR 0.3, 95% CI 0.2 to 0.7, p=0.005), irrespective of HIV status (interaction, p=0.623). BCG vaccination considerably reduced the risk of TB, both among individuals with and without HIV infection.

UR - https://www.scopus.com/pages/publications/84873745556

U2 - 10.1136/thoraxjnl-2012-201971

DO - 10.1136/thoraxjnl-2012-201971

M3 - Journal article

C2 - 22923459

SN - 0040-6376

VL - 68

SP - 288

EP - 289

JO - Thorax

JF - Thorax

IS - 3

ER -

BCG protects against tuberculosis irrespective of HIV status: a matched case-control study in Mwanza, Tanzania

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