Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  2. Hospital contacts with alcohol problems prior to liver cirrhosis or pancreatitis diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Soluble membrane attack complex in ascites in patients with liver cirrhosis without infections

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The Effect of Different Training Intensities on Oxidatively Generated Modifications of Nucleic Acids: A Randomized, Controlled Trial

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  3. Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The Liver-α-Cell Axis and Type 2 Diabetes

    Research output: Contribution to journalReviewResearchpeer-review

  5. Evaluation of clinical translatability of the diet-induced obese and biopsy-confirmed gubra amylin mouse model of non-alcoholic steatohepatitis

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

View graph of relations

Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a significant liver disease, and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis (NASH) to fibrosis, subsequent cirrhosis, end-stage liver failure, and liver cancer with a potential need for liver transplantation. NAFLD and NASH are closely related to obesity, metabolic syndrome, and type 2 diabetes (T2D). The role of gut hormones, especially glucagon-like peptide 1 (GLP-1), is important in NAFLD. Bariatric surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2D. Recent data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of NAFLD. Therefore, bariatric surgery may reverse the pathological liver changes in NAFLD and NASH patients. In the present review, we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic pathways. We performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH patients. The specific focus was liver histopathology as assessed by the invasive liver biopsy. Additionally, we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery.

Original languageEnglish
JournalWorld Journal of Hepatology
Volume11
Issue number2
Pages (from-to)138-149
Number of pages12
ISSN1948-5182
DOIs
Publication statusPublished - 27 Feb 2019

    Research areas

  • Bariatric surgery, Fibrosis, Glucagon-like peptide 1, Gut hormones, Inflammation, Insulin resistance, Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Steatosis

ID: 56845805