Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Bacterial colonization of seromas after breast cancer surgery with and without local steroid prophylaxis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Lymph node yield and tumour subsite are associated with survival in stage I-III colon cancer: results from a national cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Primary malignant mixed müllerian tumor of the peritoneum a case report with review of the literature

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence of Infective Endocarditis in Streptococcal Bloodstream Infections is Dependent on Streptococcal Species

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antibiotic-prescribing and antibiotic-resistance patterns among elderly citizens residing in two Nordic regions

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Seroma formation is a frequent postoperative sequela after mastectomy for primary breast cancer. We investigated the role of bacterial colonization of seroma fluid with three different culture methods and the effect of intracavitary steroids.

METHODS: The study group consisted of 212 patients scheduled for mastectomy from a previously performed double-blind randomized placebo-controlled intervention trial. The patients were allocated to a single dose of 80 mg of steroids (methylprednisolone) or saline, and the effect on seroma formation was investigated. From each aspiration, an equal volume of seroma fluid (10 mL) was distributed into one sterile transport tube (conventional method), one aerobic blood culture bottle and one anaerobic blood culture bottle.

RESULTS: There was significant variation in the number of bacterial species detected in seroma samples among the three culture methods, ranging from 18 species with the conventional culture tubes to 40 species with aerobic blood culture bottles. Patients receiving prophylactic steroids had significantly more frequent colonization than those in the saline group. Nevertheless, the clinical surgical site infection rate of 7.0% was equal between the two groups.

CONCLUSIONS: In general, data analysis of the entire set of case material did not succeed in demonstrating a relationship between a specific bacterial species or a combination of species and seroma formation. However, in the few patients with growth of a pathogenic species, both the duration of seroma formation and volume of seroma fluid were more pronounced.

TRIAL REGISTRATION: Ethics Committee of Copenhagen (H-4-2009-137), (EudraCT number 2009-016650-40), the Danish Data Protection Agency (code J. no. F.750.75-2), and the Danish Health and Medicines Authority (sponsor protocol code number 23837). Start date November 2010.

Original languageEnglish
JournalWorld Journal of Surgical Oncology
Issue number1
Pages (from-to)120
Publication statusPublished - 10 Jul 2019

    Research areas

  • Bacteria/isolation & purification, Bacterial Infections/etiology, Breast Neoplasms/drug therapy, Double-Blind Method, Female, Follow-Up Studies, Glucocorticoids/administration & dosage, Humans, Mastectomy/adverse effects, Methylprednisolone/administration & dosage, Prognosis, Seroma/etiology, Surgical Wound Infection/etiology

ID: 59517239