Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial

Viviana Galimberti; Bernard F Cole; Stefano Zurrida; Giuseppe Viale; Alberto Luini; Paolo Veronesi; Paola Baratella; Camelia Chifu; Manuela Sargenti; Mattia Intra; Oreste Gentilini; Mauro G Mastropasqua; Giovanni Mazzarol; Samuele Massarut; Jean-Rémi Garbay; Janez Zgajnar; Hanne Galatius; Angelo Recalcati; David Littlejohn; Monika Bamert; Marco Colleoni; Karen N Price; Meredith M Regan; Aron Goldhirsch; Alan S Coates; Richard D Gelber; Umberto Veronesi; International Breast Cancer Study Group Trial 23-01 investigators

doi:10.1016/S1470-2045(13)70035-4

Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial

Viviana Galimberti, Bernard F Cole, Stefano Zurrida, Giuseppe Viale, Alberto Luini, Paolo Veronesi, Paola Baratella, Camelia Chifu, Manuela Sargenti, Mattia Intra, Oreste Gentilini, Mauro G Mastropasqua, Giovanni Mazzarol, Samuele Massarut, Jean-Rémi Garbay, Janez Zgajnar, Hanne Galatius, Angelo Recalcati, David Littlejohn, Monika BamertMarco Colleoni, Karen N Price, Meredith M Regan, Aron Goldhirsch, Alan S Coates, Richard D Gelber, Umberto Veronesi, International Breast Cancer Study Group Trial 23-01 investigators

Department of Breast Surgery

1162 Citations (Scopus)

Abstract

For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement, axillary dissection might be overtreatment. We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm.

Original language	English
Journal	The Lancet Oncology
Volume	14
Issue number	4
Pages (from-to)	297-305
Number of pages	9
ISSN	1470-2045
DOIs	https://doi.org/10.1016/S1470-2045(13)70035-4
Publication status	Published - Apr 2013

Keywords

Adult
Aged
Axilla
Breast Neoplasms
Disease-Free Survival
Female
Follow-Up Studies
Humans
Lymph Nodes
Lymphatic Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Micrometastasis
Sentinel Lymph Node Biopsy
Treatment Outcome

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Galimberti, V., Cole, B. F., Zurrida, S., Viale, G., Luini, A., Veronesi, P., Baratella, P., Chifu, C., Sargenti, M., Intra, M., Gentilini, O., Mastropasqua, M. G., Mazzarol, G., Massarut, S., Garbay, J.-R., Zgajnar, J., Galatius, H., Recalcati, A., Littlejohn, D., ... International Breast Cancer Study Group Trial 23-01 investigators (2013). Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. The Lancet Oncology, 14(4), 297-305. https://doi.org/10.1016/S1470-2045(13)70035-4

Galimberti, V, Cole, BF, Zurrida, S, Viale, G, Luini, A, Veronesi, P, Baratella, P, Chifu, C, Sargenti, M, Intra, M, Gentilini, O, Mastropasqua, MG, Mazzarol, G, Massarut, S, Garbay, J-R, Zgajnar, J, Galatius, H, Recalcati, A, Littlejohn, D, Bamert, M, Colleoni, M, Price, KN, Regan, MM, Goldhirsch, A, Coates, AS, Gelber, RD, Veronesi, U & International Breast Cancer Study Group Trial 23-01 investigators 2013, 'Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial', The Lancet Oncology, vol. 14, no. 4, pp. 297-305. https://doi.org/10.1016/S1470-2045(13)70035-4

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abstract = "For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement, axillary dissection might be overtreatment. We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm.",

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AU - Cole, Bernard F

AU - Zurrida, Stefano

AU - Viale, Giuseppe

AU - Luini, Alberto

AU - Veronesi, Paolo

AU - Baratella, Paola

AU - Chifu, Camelia

AU - Sargenti, Manuela

AU - Intra, Mattia

AU - Gentilini, Oreste

AU - Mastropasqua, Mauro G

AU - Mazzarol, Giovanni

AU - Massarut, Samuele

AU - Garbay, Jean-Rémi

AU - Zgajnar, Janez

AU - Galatius, Hanne

AU - Recalcati, Angelo

AU - Littlejohn, David

AU - Bamert, Monika

AU - Colleoni, Marco

AU - Price, Karen N

AU - Regan, Meredith M

AU - Goldhirsch, Aron

AU - Coates, Alan S

AU - Gelber, Richard D

AU - Veronesi, Umberto

AU - International Breast Cancer Study Group Trial 23-01 investigators

PY - 2013/4

Y1 - 2013/4

N2 - For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement, axillary dissection might be overtreatment. We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm.

AB - For patients with breast cancer and metastases in the sentinel nodes, axillary dissection has been standard treatment. However, for patients with limited sentinel-node involvement, axillary dissection might be overtreatment. We designed IBCSG trial 23-01 to determine whether no axillary dissection was non-inferior to axillary dissection in patients with one or more micrometastatic (≤2 mm) sentinel nodes and tumour of maximum 5 cm.

KW - Adult

KW - Aged

KW - Axilla

KW - Breast Neoplasms

KW - Disease-Free Survival

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Middle Aged

KW - Neoplasm Grading

KW - Neoplasm Micrometastasis

KW - Sentinel Lymph Node Biopsy

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/84875804030

U2 - 10.1016/S1470-2045(13)70035-4

DO - 10.1016/S1470-2045(13)70035-4

M3 - Journal article

C2 - 23491275

SN - 1470-2045

VL - 14

SP - 297

EP - 305

JO - The Lancet Oncology

JF - The Lancet Oncology

IS - 4

ER -

Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial

Abstract

Keywords

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