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Autonomic neuropathy: cardiovascular, hormonal and metabolic studies

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@article{a20783dbbf034bde9d5d12e3901504e2,
title = "Autonomic neuropathy: cardiovascular, hormonal and metabolic studies",
abstract = "In order to elucidate the physiological significance of autonomic neuropathy in juvenile diabetics, cardiovascular, hormonal and metabolic functions have been investigated in three groups of juvenile diabetics: One group had no signs of neuropathy, one group had presumably slight autonomic neuropathy (reduced beat-to-beat variation in heart rate during hyperventilation) and one group had clinically severe autonomic neuropathy, defined by presence of orthostatic hypotension. In all three experimental situations we found sympathetic dysfunction causing cardiovascular and/or hormonal maladjustments in patients with autonomic neuropathy. Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy.",
keywords = "Blood Pressure, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Epinephrine, Heart Rate, Humans, Insulin, Norepinephrine, Physical Exertion, Pressoreceptors",
author = "J Hilsted",
year = "1980",
language = "English",
volume = "238",
pages = "139--44",
journal = "Acta Endocrinologica, Supplement",
issn = "0300-9750",
publisher = "Ejnar Munksgaard",

}

RIS

TY - JOUR

T1 - Autonomic neuropathy

T2 - cardiovascular, hormonal and metabolic studies

AU - Hilsted, J

PY - 1980

Y1 - 1980

N2 - In order to elucidate the physiological significance of autonomic neuropathy in juvenile diabetics, cardiovascular, hormonal and metabolic functions have been investigated in three groups of juvenile diabetics: One group had no signs of neuropathy, one group had presumably slight autonomic neuropathy (reduced beat-to-beat variation in heart rate during hyperventilation) and one group had clinically severe autonomic neuropathy, defined by presence of orthostatic hypotension. In all three experimental situations we found sympathetic dysfunction causing cardiovascular and/or hormonal maladjustments in patients with autonomic neuropathy. Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy.

AB - In order to elucidate the physiological significance of autonomic neuropathy in juvenile diabetics, cardiovascular, hormonal and metabolic functions have been investigated in three groups of juvenile diabetics: One group had no signs of neuropathy, one group had presumably slight autonomic neuropathy (reduced beat-to-beat variation in heart rate during hyperventilation) and one group had clinically severe autonomic neuropathy, defined by presence of orthostatic hypotension. In all three experimental situations we found sympathetic dysfunction causing cardiovascular and/or hormonal maladjustments in patients with autonomic neuropathy. Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy.

KW - Blood Pressure

KW - Diabetes Mellitus, Type 1

KW - Diabetic Neuropathies

KW - Epinephrine

KW - Heart Rate

KW - Humans

KW - Insulin

KW - Norepinephrine

KW - Physical Exertion

KW - Pressoreceptors

M3 - Journal article

VL - 238

SP - 139

EP - 144

JO - Acta Endocrinologica, Supplement

JF - Acta Endocrinologica, Supplement

SN - 0300-9750

ER -

ID: 40162551