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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Autonomic neuropathy: cardiovascular, hormonal and metabolic studies

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  1. Rapid changes in kidney function--factors influencing kidney function in diabetics and normal man

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  2. Measurement of blood flow with freely diffusible indicators as inert gases, antipyrine, labelled water and rubidium

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In order to elucidate the physiological significance of autonomic neuropathy in juvenile diabetics, cardiovascular, hormonal and metabolic functions have been investigated in three groups of juvenile diabetics: One group had no signs of neuropathy, one group had presumably slight autonomic neuropathy (reduced beat-to-beat variation in heart rate during hyperventilation) and one group had clinically severe autonomic neuropathy, defined by presence of orthostatic hypotension. In all three experimental situations we found sympathetic dysfunction causing cardiovascular and/or hormonal maladjustments in patients with autonomic neuropathy. Regarding metabolic functions we found normal responses to graded exercise and insulin-induced hypoglycemia in patients with autonomic neuropathy in spite of blunted catecholamine responses, suggesting increased sensitivity of glycogen stores and adipose tissue towards the action of catecholamine in patients with autonomic neuropathy.
Original languageEnglish
JournalActa endocrinologica. Supplementum
Volume238
Pages (from-to)139-44
Number of pages6
ISSN0300-9750
Publication statusPublished - 1980

    Research areas

  • Blood Pressure, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Epinephrine, Heart Rate, Humans, Insulin, Norepinephrine, Physical Exertion, Pressoreceptors

ID: 40162551