Author correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Itziar de Rojas; Sonia Moreno-Grau; Niccolo Tesi; Victor Andrade; Iris E Jansen; Nancy L Pedersen; Najada Stringa; Anna Zettergren; Isabel Hernández; Laura Montrreal; Carmen Antúnez; Anna Antonell; Rick M Tankard; Joshua C Bis; Rebecca Sims; Céline Bellenguez; Inés Quintela; Antonio González-Perez; Miguel Calero; Emilio Franco-Macías; Juan Macías; Rafael Blesa; Laura Cervera-Carles; Manuel Menéndez-González; Ana Frank-García; Jose Luís Royo; Fermin Moreno; Raquel Huerto Vilas; Miquel Baquero; Mónica Diez-Fairen; Carmen Lage; Sebastián García-Madrona; Pablo García-González; Emilio Alarcón-Martín; Sergi Valero; Oscar Sotolongo-Grau; Abbe Ullgren; Adam C Naj; Afina W Lemstra; Alba Benaque; Alba Pérez-Cordón; Alberto Benussi; Alberto Rábano; Alessandro Padovani; Anne Tybjærg-Hansen; Børge G Nordestgaard; Jesper Qvist Thomassen; Michael Wagner; Ruth Frikke-Schmidt; EADB contributors

doi:10.1038/s41467-021-22491-8

Author correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Victor Andrade, Iris E Jansen, Nancy L Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernández, Laura Montrreal, Carmen Antúnez, Anna Antonell, Rick M Tankard, Joshua C Bis, Rebecca Sims, Céline Bellenguez, Inés Quintela, Antonio González-Perez, Miguel Calero, Emilio Franco-MacíasJuan Macías, Rafael Blesa, Laura Cervera-Carles, Manuel Menéndez-González, Ana Frank-García, Jose Luís Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Mónica Diez-Fairen, Carmen Lage, Sebastián García-Madrona, Pablo García-González, Emilio Alarcón-Martín, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C Naj, Afina W Lemstra, Alba Benaque, Alba Pérez-Cordón, Alberto Benussi, Alberto Rábano, Alessandro Padovani, Anne Tybjærg-Hansen, Børge G Nordestgaard, Jesper Qvist Thomassen, Michael Wagner, Ruth Frikke-Schmidt, EADB contributors

Abstract

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.

Original language	English
Publication date	Dec 2023
Edition	1
Volume	14
Number of pages	1
DOIs	https://doi.org/10.1038/s41467-021-22491-8
Publication status	Published - Dec 2023

Series	Nature Communications
ISSN	2041-1722

Keywords

Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease/epidemiology
Amyloid beta-Protein Precursor/genetics
Apolipoproteins E/genetics
Case-Control Studies
Cohort Studies
Datasets as Topic
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Heterozygote
Humans
Male
Middle Aged
Multifactorial Inheritance
Polymorphism, Single Nucleotide
Risk Assessment/methods
Risk Factors

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de Rojas, I., Moreno-Grau, S., Tesi, N., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., Calero, M., ... EADB contributors (2023, Dec). Author correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. (1 ed.) Nature Communications https://doi.org/10.1038/s41467-021-22491-8

de Rojas, I, Moreno-Grau, S, Tesi, N, Andrade, V, Jansen, IE, Pedersen, NL, Stringa, N, Zettergren, A, Hernández, I, Montrreal, L, Antúnez, C, Antonell, A, Tankard, RM, Bis, JC, Sims, R, Bellenguez, C, Quintela, I, González-Perez, A, Calero, M, Franco-Macías, E, Macías, J, Blesa, R, Cervera-Carles, L, Menéndez-González, M, Frank-García, A, Royo, JL, Moreno, F, Huerto Vilas, R, Baquero, M, Diez-Fairen, M, Lage, C, García-Madrona, S, García-González, P, Alarcón-Martín, E, Valero, S, Sotolongo-Grau, O, Ullgren, A, Naj, AC, Lemstra, AW, Benaque, A, Pérez-Cordón, A, Benussi, A, Rábano, A, Padovani, A, Tybjærg-Hansen, A , Nordestgaard, BG , Thomassen, JQ, Wagner, M, Frikke-Schmidt, R & EADB contributors 2023, Author correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.. https://doi.org/10.1038/s41467-021-22491-8

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abstract = "Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.",

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AU - Moreno-Grau, Sonia

AU - Tesi, Niccolo

AU - Andrade, Victor

AU - Jansen, Iris E

AU - Pedersen, Nancy L

AU - Stringa, Najada

AU - Zettergren, Anna

AU - Hernández, Isabel

AU - Montrreal, Laura

AU - Antúnez, Carmen

AU - Antonell, Anna

AU - Tankard, Rick M

AU - Bis, Joshua C

AU - Sims, Rebecca

AU - Bellenguez, Céline

AU - Quintela, Inés

AU - González-Perez, Antonio

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AU - Franco-Macías, Emilio

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AU - Blesa, Rafael

AU - Cervera-Carles, Laura

AU - Menéndez-González, Manuel

AU - Frank-García, Ana

AU - Royo, Jose Luís

AU - Moreno, Fermin

AU - Huerto Vilas, Raquel

AU - Baquero, Miquel

AU - Diez-Fairen, Mónica

AU - Lage, Carmen

AU - García-Madrona, Sebastián

AU - García-González, Pablo

AU - Alarcón-Martín, Emilio

AU - Valero, Sergi

AU - Sotolongo-Grau, Oscar

AU - Ullgren, Abbe

AU - Naj, Adam C

AU - Lemstra, Afina W

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AU - Rábano, Alberto

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AU - Tybjærg-Hansen, Anne

AU - Nordestgaard, Børge G

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AU - Wagner, Michael

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KW - Cohort Studies

KW - Datasets as Topic

KW - Female

KW - Follow-Up Studies

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KW - Genome-Wide Association Study

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

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M3 - Other contribution

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VL - 14

T3 - Nature Communications

ER -

Author correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

Abstract

Keywords

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