Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

Maria van Gennip; Claus Moser; Louise D Christensen; Thomas Bjarnsholt; Henrik Calum; Peter Ø Jensen; Lars Christophersen; Hans Petter Hougen; Oana Ciofu; Søren Molin; Michael Givskov; Niels Høiby

doi:10.1093/jac/dkp352

Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

Maria van Gennip
, Claus Moser
, Louise D Christensen
, Thomas Bjarnsholt
, Henrik Calum
, Peter Ø Jensen
, Lars Christophersen
, Hans Petter Hougen
, Oana Ciofu
, Søren Molin
, Michael Givskov
, Niels Høiby

Department of Clinical Microbiology

22 Citations (Scopus)

Abstract

Effects of treatment with tobramycin initiated 1 or 24 h post-infection were investigated in a new version of a pulmonary infection model in mice. The model reflects the differentiated behaviour of Pseudomonas aeruginosa mucoid strains isolated from the lungs of one chronically infected cystic fibrosis (CF) patient at different time periods during chronic lung infection.

Original language	English
Journal	Journal of Antimicrobial Chemotherapy
Volume	64
Issue number	6
Pages (from-to)	1241-50
Number of pages	10
ISSN	0305-7453
DOIs	https://doi.org/10.1093/jac/dkp352
Publication status	Published - 1 Dec 2009

Keywords

Animals
Anti-Bacterial Agents
Chemokine CXCL2
Colony Count, Microbial
Cystic Fibrosis
Disease Models, Animal
Female
Granulocyte Colony-Stimulating Factor
Humans
Lung
Mice
Mice, Inbred BALB C
Pneumonia, Bacterial
Pseudomonas Infections
Pseudomonas aeruginosa
Severity of Illness Index
Time Factors
Tobramycin

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van Gennip, M., Moser, C., Christensen, L. D., Bjarnsholt, T., Calum, H., Jensen, P. Ø., Christophersen, L., Hougen, H. P., Ciofu, O., Molin, S., Givskov, M., & Høiby, N. (2009). Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy, 64(6), 1241-50. https://doi.org/10.1093/jac/dkp352

Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa. / van Gennip, Maria; Moser, Claus; Christensen, Louise D et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 64, No. 6, 01.12.2009, p. 1241-50.

Research output: Contribution to journal › Journal article › Research › peer-review

van Gennip, M, Moser, C, Christensen, LD, Bjarnsholt, T, Calum, H, Jensen, PØ, Christophersen, L, Hougen, HP, Ciofu, O, Molin, S, Givskov, M & Høiby, N 2009, 'Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa', Journal of Antimicrobial Chemotherapy, vol. 64, no. 6, pp. 1241-50. https://doi.org/10.1093/jac/dkp352

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abstract = "Effects of treatment with tobramycin initiated 1 or 24 h post-infection were investigated in a new version of a pulmonary infection model in mice. The model reflects the differentiated behaviour of Pseudomonas aeruginosa mucoid strains isolated from the lungs of one chronically infected cystic fibrosis (CF) patient at different time periods during chronic lung infection.",

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AU - Calum, Henrik

AU - Jensen, Peter Ø

AU - Christophersen, Lars

AU - Hougen, Hans Petter

AU - Ciofu, Oana

AU - Molin, Søren

AU - Givskov, Michael

AU - Høiby, Niels

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KW - Disease Models, Animal

KW - Female

KW - Granulocyte Colony-Stimulating Factor

KW - Humans

KW - Lung

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KW - Mice, Inbred BALB C

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Augmented effect of early antibiotic treatment in mice with experimental lung infections due to sequentially adapted mucoid strains of Pseudomonas aeruginosa

Abstract

Keywords

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