Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Auditory sensory gating in young adolescents with early-onset psychosis: a comparison with attention deficit/hyperactivity disorder: a comparison with attention deficit/hyperactivity disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of muscarinic M1 receptor stimulation on reinforcing and neurochemical effects of cocaine in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sex differences in opioid reinforcement under a fentanyl vs. food choice procedure in rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Skizofreniens neuropsykologi

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  2. Somatiske årsager til akut opståede psykiatriske tilstande hos børn og unge

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Numerous studies have demonstrated impaired sensory gating in schizophrenia and this impairment has been proposed as a candidate biomarker for the disorder. The typical age of onset for schizophrenia is early adulthood, however a sizable group of patients present with psychotic symptoms before the age of 18, commonly referred to as early-onset psychosis (EOP). How an earlier onset influences sensory gating is currently unknown. Impaired sensory gating may not be specific to psychosis, but rather a shared disturbance of neurodevelopmental disorders, such as attention deficit/hyperactivity disorder (ADHD). Therefore, the current study investigated P50 suppression in young adolescents (12-17 years old) with either EOP (N = 55) or ADHD (N = 28) and age and gender matched healthy controls (HC) (N = 71). In addition to P50 suppression, N100 and P200 suppression data were also analyzed. No significant group differences in either raw mean P50 amplitude or mean P50 gating ratios were observed between EOP, ADHD, and HC. Additionally, we observed no P50 suppression deficit in those EOP patients diagnosed with schizophrenia (N = 39). Similarly, we observed no differences in N100 or P200 between the three groups. Healthy levels of P50 suppression were found in both patient groups. The results are in line with some previous studies showing healthy levels of P50 suppression in the early phases of schizophrenia. Our findings do not support P50 sensory gating as a valid biomarker for EOP or ADHD.

Original languageEnglish
Article number45(4)
JournalNeuropsychopharmacology
Volume45
Issue number4
Pages (from-to)649-655
Number of pages7
ISSN0893-133X
DOIs
Publication statusPublished - Mar 2020

ID: 58217194