Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Atypical sleep in critically ill patients on mechanical ventilation is associated with increased mortality

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Sleep-disordered breathing and cerebral small vessel disease-acute and 6 months after ischemic stroke

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Answer to "On the importance of polysomnography after stroke"

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Polysomnographic indicators of mortality in stroke patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Arousal characteristics in patients with Parkinson's disease and isolated rapid eye movement sleep behavior disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Brain tumours in children and adolescents may affect the circadian rhythm and quality of life

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Brain tumours result in sleep disorders in children and adolescents

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. European guideline and expert statements on the management of narcolepsy in adults and children

    Research output: Contribution to journalReviewResearchpeer-review

  5. Automatic Segmentation to Cluster Patterns of Breathing in Sleep Apnea

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Sleep patterns in critically ill patients' polysomnographic sleep studies (PSG) are severely abnormal.

PURPOSE: We aimed to investigate the association of atypical sleep patterns, micro-sleep phenomena (sleep spindles and K-complexes) and rapid eye movement (REM) sleep with intensive care unit (ICU), in-hospital and 90-day mortality in conscious critically ill patients on mechanical ventilation.

METHOD: This was a prospective descriptive study. We analysed 52 PSGs recorded in conscious critically ill patients on mechanical ventilation. PSGs were scored according to standard classification when possible. Otherwise, modified classification proposed for scoring sleep in critically ill patients was used. The association of PSG findings with mortality was studied using logistic regression and Weibull model of survival analysis.

RESULTS: The presence of atypical sleep patterns in accordance with modified sleep scoring classification was associated with higher odds for ICU mortality (odds ratio 11.63; p = 0.03). The absence of K-complexes was associated with higher odds for ICU mortality (odds ratio 11.63; p = 0.03), while the absence of sleep spindles was associated with higher odds for in-hospital (odds ratio 7.80; p = 0.02) and 90-day mortality (odds ratio 5.51; p = 0.02). Loss of sleep spindles was associated with higher mortality risk with cutoff point 90 days (hazard ratio 3.87; p = 0.03).

CONCLUSIONS: The presence of atypical sleep and absence of normal PSG sleep characteristics in conscious critically ill patients on mechanical ventilation indicates involvement of sleep producing brain structures in the pathological process and is associated with poor outcome.

Original languageEnglish
JournalSleep & breathing = Schlaf & Atmung
Volume23
Issue number1
Pages (from-to)379-388
Number of pages10
ISSN1520-9512
DOIs
Publication statusPublished - Mar 2019

    Research areas

  • Atypical sleep, Critically ill patients, Polysomnography, Sleep scoring classification

ID: 56226219