Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Attenuated purinergic receptor function in patients with type 2 diabetes
AU - Thaning, Pia
AU - Bune, Laurids T
AU - Hellsten, Ylva
AU - Pilegaard, Henriette
AU - Saltin, Bengt
AU - Rosenmeier, Jaya B
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.
AB - Extracellular nucleotides and nucleosides are involved in regulation of skeletal muscle blood flow. Diabetes induces cardiovascular dysregulation, but the extent to which the vasodilatatory capacity of nucleotides and nucleosides is affected in type 2 diabetes is unknown. The present study investigated 1) the vasodilatatory effect of ATP, uridine-triphosphate (UTP), and adenosine (ADO) and 2) the expression and distribution of P2Y(2) and P2X(1) receptors in skeletal muscles of diabetic subjects.
U2 - 10.2337/db09-1068
DO - 10.2337/db09-1068
M3 - Journal article
VL - 59
SP - 182
EP - 189
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 1
ER -
ID: 32249418