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The Capital Region of Denmark - a part of Copenhagen University Hospital

Attempts to Target Staphylococcus aureus Induced Osteomyelitis Bone Lesions in a Juvenile Pig Model by Using Radiotracers

Research output: Contribution to journalJournal articleResearchpeer-review

  1. [99mTc]-labelled interleukin-8 as a diagnostic tool compared to [18F]FDG and CT in an experimental porcine osteomyelitis model

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of Animal Models in Molecular Imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Pia Afzelius
  • Aage Kristian Olsen Alstrup
  • Ole Lerberg Nielsen
  • Karin Michaelsen Nielsen
  • Svend Borup Jensen
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Background [18F]FDG Positron Emission Tomography cannot differentiate between sterile inflammation and infection. Therefore, we, aimed to develop more specific radiotracers fitted for differentiation between sterile and septic infection to improve the diagnostic accuracy. Consequently, the clinicians can refine the treatment of, for example, prosthesis-related infection.

METHODS: We examined different target points; Staphylococcus aureus biofilm (68Ga-labeled DOTA-K-A9 and DOTA-GSGK-A11), bone remodeling ([18F]NaF), bacterial cell membranes ([68Ga]Ga-Ubiquicidin), and leukocyte trafficking ([68Ga]Ga-DOTA-Siglec-9). We compared them to the well-known glucose metabolism marker [18F]FDG, in a well-established juvenile S. aureus induced osteomyelitis (OM) pig model.

RESULTS: [18F]FDG accumulated in the OM lesions seven days after bacterial inoculation, but disappointingly we were not able to identify any tracer accumulation in OM with any of the supposedly more specific tracers.

CONCLUSION: These negative results are, however, relevant to report as they may save other research groups from conducting the same animal experiments and provide a platform for developing and evaluating other new potential tracers or protocol instead.

Original languageEnglish
Article numberE4329
Issue number18
Publication statusPublished - 21 Sep 2020

ID: 60905301