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Atrial secretion of B-type natriuretic peptide

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@article{c7ec7b38fed14d6681caf0d5d75f6d23,
title = "Atrial secretion of B-type natriuretic peptide",
abstract = "In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how.",
keywords = "Atrial Fibrillation, Heart Atria, Heart Failure, Humans, Microscopy, Confocal, Myocytes, Cardiac, Natriuretic Peptide, Brain, Journal Article, Review",
author = "Goetze, {Jens Peter} and Lennart Friis-Hansen and Rehfeld, {Jens F} and Brian Nilsson and Svendsen, {Jesper Hastrup}",
year = "2006",
month = "7",
doi = "10.1093/eurheartj/ehl109",
language = "English",
volume = "27",
pages = "1648--50",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "14",

}

RIS

TY - JOUR

T1 - Atrial secretion of B-type natriuretic peptide

AU - Goetze, Jens Peter

AU - Friis-Hansen, Lennart

AU - Rehfeld, Jens F

AU - Nilsson, Brian

AU - Svendsen, Jesper Hastrup

PY - 2006/7

Y1 - 2006/7

N2 - In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how.

AB - In the normal heart, the endocrine capacity resides in the atria. Atrial myocytes express and secrete natriuretic hormones that regulate fluid homeostasis and blood pressure. But in ventricular disease, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) gene expression is also activated in ventricular myocytes. Plasma concentrations of natriuretic peptides and their biosynthetic precursors are accordingly increased in patients with marked ventricular dysfunction. In contrast, atrial peptide secretion in ventricular disease has received less attention, and our present understanding of the endocrine atria during ventricular dysfunction is still scarce. Although ventricular disease and increased circulating concentrations are associated, it does not entail that the ventricle is the sole or even the main source in all types of heart disease. Clearly, the endocrine atria are also active in heart failure. Plasma measurement of cardiac natriuretic peptides and their molecular precursors can perhaps help us to discriminate when, where and how.

KW - Atrial Fibrillation

KW - Heart Atria

KW - Heart Failure

KW - Humans

KW - Microscopy, Confocal

KW - Myocytes, Cardiac

KW - Natriuretic Peptide, Brain

KW - Journal Article

KW - Review

U2 - 10.1093/eurheartj/ehl109

DO - 10.1093/eurheartj/ehl109

M3 - Journal article

VL - 27

SP - 1648

EP - 1650

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 14

ER -

ID: 51560919