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Atrial natriuretic peptide, copeptin and adrenomedullin levels in polycystic ovary syndrome: a case-control study

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  1. Low dose HP-hMG in an antagonist protocol for IVF in ovulatory and anovulatory patients with high AMH

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  2. The impact of gastric bypass surgery on sex hormones and menstrual cycles in premenopausal women

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  3. Left-right differences in ovarian volume and antral follicle count in 1423 women of reproductive age

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  4. Selective use of corifollitropin for controlled ovarian stimulation for IVF in patients with low anti-Müllerian hormone

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  5. Endogenous thrombin potential in polycystic ovary syndrome: the association to body mass index, insulin resistance, and inflammation

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  1. Empagliflozin in heart failure patients with reduced ejection fraction: a randomized clinical trial (Empire HF)

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  2. Effects of Dapagliflozin on Volume Status When Added to Renin-Angiotensin System Inhibitors

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  3. Prevalence of heart failure and the diagnostic value of MR-proANP in outpatients with type 2 diabetes

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BACKGROUND: Polycystic ovary syndrome (PCOS) defined by the Rotterdam criteria does not take into account the unhealthy metabolic profile of the syndrome with increased insulin resistance (IR) and overweight favoring development of type 2 diabetes, hypertension and cardiovascular disease (CVD). We assess three vasoactive peptides associated with CVD in women with PCOS.

METHOD: Plasma levels of mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin and mid-regional pro-adrenomedullin (MR-proADM) were measured in 98 PCOS patients and 46 age- and BMI-matched healthy women.

RESULTS: We found no difference in levels of MR-proANP, copeptin and MR-proADM between the PCOS and control group. Multiple regression analyses on a combined group of PCOS and control subjects demonstrated an inverse correlation between MR-proANP and IR (measured by fasting C-peptide) and a positive correlations between copeptin and IR as well as MR-proADM and BMI. We found no association between peptide levels and different Rotterdam phenotypes.

CONCLUSION: Plasma concentrations of MR-proANP, copeptin and MR-proADM were not increased in PCOS compared to age- and BMI-matched controls. Thus, these peptides cannot be used to detect increased risk of CVD in a young PCOS cohort.

Original languageEnglish
JournalGynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Volume33
Issue number1
Pages (from-to)30-33
Number of pages4
DOIs
Publication statusPublished - Jan 2017

ID: 49865261