TY - JOUR
T1 - Atrial fibrillation burden and cognitive decline in elderly patients undergoing continuous monitoring
AU - Bonnesen, Mathias Pinto
AU - Diederichsen, Søren Zöga
AU - Isaksen, Jonas L
AU - Frederiksen, Kristian Steen
AU - Hasselbalch, Steen Gregers
AU - Haugan, Ketil Jørgen
AU - Kronborg, Christian
AU - Graff, Claus
AU - Højberg, Søren
AU - Køber, Lars
AU - Krieger, Derk W
AU - Brandes, Axel
AU - Svendsen, Jesper Hastrup
N1 - Copyright © 2021. Published by Elsevier Inc.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - AIMS: To study the relationship between subclinical atrial fibrillation (AF) and changes in cognitive function in a large cohort of individuals with stroke risk factors.METHODS: Individuals with no prior AF diagnosis but with risk factors for stroke were recruited to undergo annual cognitive assessment with the Montreal Cognitive Assessment (MoCA) along with implantable loop recorder (ILR) monitoring for AF for 3 years. If AF episodes lasting ≥6 minutes were detected, oral anticoagulation (OAC) treatment was initiated.RESULTS: A total of 1194 participants (55.2 % men, mean age 74.5 (±3.9)) had a combined duration of heart rhythm monitoring of ≈1.3 million days. Among these, 339 participants (28.3%) had adjudicated AF, with a median AF burden of 0.072% (0.02, 0.39), and 324 (96%) initiated OAC. When stratifying the participants into AF burden groups (No AF, AFlow (AF burden <0.25%), and AFhigh, (AF burden >0.25%)), only participants in the AFlow group had a decrease in MoCA score over time (P = .03), although this was not significant after adjustment for stroke risk factors. A subgroup analysis of 175 participants (14.6%) with a MoCA <26 at 3 years found no association to AF diagnosis or burden.CONCLUSIONS: In a high-risk population, subclinical AF detected by continuous monitoring and subsequently treated with OAC was not associated with a significant change in MoCA score over a 3-year period.
AB - AIMS: To study the relationship between subclinical atrial fibrillation (AF) and changes in cognitive function in a large cohort of individuals with stroke risk factors.METHODS: Individuals with no prior AF diagnosis but with risk factors for stroke were recruited to undergo annual cognitive assessment with the Montreal Cognitive Assessment (MoCA) along with implantable loop recorder (ILR) monitoring for AF for 3 years. If AF episodes lasting ≥6 minutes were detected, oral anticoagulation (OAC) treatment was initiated.RESULTS: A total of 1194 participants (55.2 % men, mean age 74.5 (±3.9)) had a combined duration of heart rhythm monitoring of ≈1.3 million days. Among these, 339 participants (28.3%) had adjudicated AF, with a median AF burden of 0.072% (0.02, 0.39), and 324 (96%) initiated OAC. When stratifying the participants into AF burden groups (No AF, AFlow (AF burden <0.25%), and AFhigh, (AF burden >0.25%)), only participants in the AFlow group had a decrease in MoCA score over time (P = .03), although this was not significant after adjustment for stroke risk factors. A subgroup analysis of 175 participants (14.6%) with a MoCA <26 at 3 years found no association to AF diagnosis or burden.CONCLUSIONS: In a high-risk population, subclinical AF detected by continuous monitoring and subsequently treated with OAC was not associated with a significant change in MoCA score over a 3-year period.
UR - http://www.scopus.com/inward/record.url?scp=85121477006&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2021.08.006
DO - 10.1016/j.ahj.2021.08.006
M3 - Journal article
C2 - 34428441
SN - 0002-8703
VL - 242
SP - 15
EP - 23
JO - American Heart Journal
JF - American Heart Journal
ER -