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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  • Mark E Lobatto
  • Claudia Calcagno
  • Antoine Millon
  • Max L Senders
  • Francois Fay
  • Philip M Robson
  • Sarayu Ramachandran
  • Tina Binderup
  • Maarten P M Paridaans
  • Steven Sensarn
  • Stephan Rogalla
  • Ronald E Gordon
  • Luis Cardoso
  • Gert Storm
  • Josbert M Metselaar
  • Christopher H Contag
  • Erik S G Stroes
  • Zahi A Fayad
  • Willem J M Mulder
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Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.

Original languageEnglish
JournalACS Nano
Volume9
Issue number2
Pages (from-to)1837-47
Number of pages11
ISSN1936-0851
DOIs
Publication statusPublished - 24 Feb 2015

    Research areas

  • Animals, Capillary Permeability, Fluorescent Dyes, Male, Multimodal Imaging, Nanoparticles, Plaque, Atherosclerotic, Rabbits, Time Factors, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

ID: 49876687