Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Mark E Lobatto; Claudia Calcagno; Antoine Millon; Max L Senders; Francois Fay; Philip M Robson; Sarayu Ramachandran; Tina Binderup; Maarten P M Paridaans; Steven Sensarn; Stephan Rogalla; Ronald E Gordon; Luis Cardoso; Gert Storm; Josbert M Metselaar; Christopher H Contag; Erik S G Stroes; Zahi A Fayad; Willem J M Mulder

doi:10.1021/nn506750r

Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Mark E Lobatto, Claudia Calcagno, Antoine Millon, Max L Senders, Francois Fay, Philip M Robson, Sarayu Ramachandran, Tina Binderup, Maarten P M Paridaans, Steven Sensarn, Stephan Rogalla, Ronald E Gordon, Luis Cardoso, Gert Storm, Josbert M Metselaar, Christopher H Contag, Erik S G Stroes, Zahi A Fayad, Willem J M Mulder

Department of Clinical Physiology, Nuclear Medicine & PET

110 Citations (Scopus)

Abstract

Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.

Original language	English
Journal	ACS Nano
Volume	9
Issue number	2
Pages (from-to)	1837-47
Number of pages	11
ISSN	1936-0851
DOIs	https://doi.org/10.1021/nn506750r
Publication status	Published - 24 Feb 2015

Keywords

Animals
Capillary Permeability
Fluorescent Dyes
Male
Multimodal Imaging
Nanoparticles
Plaque, Atherosclerotic
Rabbits
Time Factors
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

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10.1021/nn506750r

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Lobatto, M. E., Calcagno, C., Millon, A., Senders, M. L., Fay, F., Robson, P. M., Ramachandran, S., Binderup, T., Paridaans, M. P. M., Sensarn, S., Rogalla, S., Gordon, R. E., Cardoso, L., Storm, G., Metselaar, J. M., Contag, C. H., Stroes, E. S. G., Fayad, Z. A., & Mulder, W. J. M. (2015). Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. ACS Nano, 9(2), 1837-47. https://doi.org/10.1021/nn506750r

Lobatto, ME, Calcagno, C, Millon, A, Senders, ML, Fay, F, Robson, PM, Ramachandran, S, Binderup, T, Paridaans, MPM, Sensarn, S, Rogalla, S, Gordon, RE, Cardoso, L, Storm, G, Metselaar, JM, Contag, CH, Stroes, ESG, Fayad, ZA & Mulder, WJM 2015, 'Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging', ACS Nano, vol. 9, no. 2, pp. 1837-47. https://doi.org/10.1021/nn506750r

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abstract = "Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.",

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AU - Ramachandran, Sarayu

AU - Binderup, Tina

AU - Paridaans, Maarten P M

AU - Sensarn, Steven

AU - Rogalla, Stephan

AU - Gordon, Ronald E

AU - Cardoso, Luis

AU - Storm, Gert

AU - Metselaar, Josbert M

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AB - Atherosclerosis is a major cause of global morbidity and mortality that could benefit from novel targeted therapeutics. Recent studies have shown efficient and local drug delivery with nanoparticles, although the nanoparticle targeting mechanism for atherosclerosis has not yet been fully elucidated. Here we used in vivo and ex vivo multimodal imaging to examine permeability of the vessel wall and atherosclerotic plaque accumulation of fluorescently labeled liposomal nanoparticles in a rabbit model. We found a strong correlation between permeability as established by in vivo dynamic contrast enhanced magnetic resonance imaging and nanoparticle plaque accumulation with subsequent nanoparticle distribution throughout the vessel wall. These key observations will enable the development of nanotherapeutic strategies for atherosclerosis.

KW - Animals

KW - Capillary Permeability

KW - Fluorescent Dyes

KW - Male

KW - Multimodal Imaging

KW - Nanoparticles

KW - Plaque, Atherosclerotic

KW - Rabbits

KW - Time Factors

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

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DO - 10.1021/nn506750r

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SP - 1837

EP - 1847

JO - ACS Nano

JF - ACS Nano

IS - 2

ER -

Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging

Abstract

Keywords

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