Celeste Porsbjerg, Erik Melén, Lauri Lehtimäki, Dominick Shaw


Asthma is one of the most common chronic non-communicable diseases worldwide and is characterised by variable airflow obstruction, causing dyspnoea and wheezing. Highly effective therapies are available; asthma morbidity and mortality have vastly improved in the past 15 years, and most patients can attain good asthma control. However, undertreatment is still common, and improving patient and health-care provider understanding of when and how to adjust treatment is crucial. Asthma management consists of a cycle of assessment of asthma control and risk factors and adjustment of medications accordingly. With the introduction of biological therapies, management of severe asthma has entered the precision medicine era-a shift that is driving clinical ambitions towards disease remission. Patients with severe asthma often have co-existing conditions contributing to their symptoms, mandating a multidimensional management approach. In this Seminar, we provide a clinically focused overview of asthma; epidemiology, pathophysiology, diagnosis, and management in children and adults.

Original languageEnglish
Issue number10379
Pages (from-to)858-873
Number of pages16
Publication statusPublished - 11 Mar 2023


  • Adult
  • Asthma/drug therapy
  • Child
  • Dyspnea
  • Humans
  • Lung
  • Morbidity
  • Respiratory Sounds/etiology


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