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Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice

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  1. Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The Safety of Second-Generation Antipsychotics During Pregnancy: A Clinically Focused Review

    Research output: Contribution to journalReviewResearchpeer-review

  4. Monoclonal Antibodies for Relapsing Multiple Sclerosis: A Review of Recently Marketed and Late-Stage Agents

    Research output: Contribution to journalReviewResearchpeer-review

  5. Pharmacokinetic Variability of Drugs Used for Prophylactic Treatment of Migraine

    Research output: Contribution to journalReviewResearchpeer-review

  1. Clinical Manifestations of the Epsilonproteobacteria (Helicobacter pylori)

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  2. Gastric Microbiota and Resistance to Antibiotics

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducationpeer-review

  3. Infection with Rothia mucilaginosa: Review of Findings at a Danish Tertiary Hospital and Reports in Literature

    Research output: Contribution to journalJournal articleResearchpeer-review

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Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production. Adequate nutritional status, especially frequent consumption of dietary antioxidants, appears to protect against infection with H. pylori. The aim of the present study was to investigate whether astaxanthin (AXT) from shrimp cephalothorax may modulate cytokine release of splenocytes in H. pylori-infected mice (n = 60). Six- to eight-week-old female mice were divided into three groups (n = 20 per group) to receive a daily oral dose of 10 or 40 mg of AXT for six weeks. After six weeks, a trend toward interferon gamma (IFN-γ) upregulation was found (40 mg; p < 0.05) and a significant dose-dependent increase of interleukin 2 (IL-2) and IL-10 (both p < 0.05) was observed. These results suggest that AXT induces higher levels of IL-2 and a shift to a balanced Th1/Th2 response by increasing IFN-γ and augmenting IL-10. We concluded that AXT may influence the pattern of cytokines during H. pylori infection.

Original languageEnglish
JournalCNS Drugs
Volume17
Issue number7
ISSN1172-7047
DOIs
Publication statusPublished - 26 Jun 2019

ID: 59012754