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Associations of serum potassium levels with mortality in chronic heart failure patients

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Aldahl, M, Jensen, A-SC, Davidsen, L, Eriksen, MA, Møller Hansen, S, Nielsen, BJ, Krogager, ML, Køber, L, Torp-Pedersen, C & Søgaard, P 2017, 'Associations of serum potassium levels with mortality in chronic heart failure patients' European Heart Journal, vol. 38, no. 38, pp. 2890-2896. https://doi.org/10.1093/eurheartj/ehx460

APA

Aldahl, M., Jensen, A-S. C., Davidsen, L., Eriksen, M. A., Møller Hansen, S., Nielsen, B. J., ... Søgaard, P. (2017). Associations of serum potassium levels with mortality in chronic heart failure patients. European Heart Journal, 38(38), 2890-2896. https://doi.org/10.1093/eurheartj/ehx460

CBE

MLA

Vancouver

Aldahl M, Jensen A-SC, Davidsen L, Eriksen MA, Møller Hansen S, Nielsen BJ et al. Associations of serum potassium levels with mortality in chronic heart failure patients. European Heart Journal. 2017 Oct 7;38(38):2890-2896. https://doi.org/10.1093/eurheartj/ehx460

Author

Aldahl, Mette ; Jensen, Anne-Sofie Caroline ; Davidsen, Line ; Eriksen, Matilde Alida ; Møller Hansen, Steen ; Nielsen, Berit Jamie ; Krogager, Maria Lukács ; Køber, Lars ; Torp-Pedersen, Christian ; Søgaard, Peter. / Associations of serum potassium levels with mortality in chronic heart failure patients. In: European Heart Journal. 2017 ; Vol. 38, No. 38. pp. 2890-2896.

Bibtex

@article{e3affb48843e460e80e901e217f6069e,
title = "Associations of serum potassium levels with mortality in chronic heart failure patients",
abstract = "Aims: Medication prescribed to patients suffering from chronic heart failure carries an increased risk of impaired potassium homeostasis. We examined the relation between different levels of serum potassium and mortality among patients with chronic heart failure.Methods and results: From Danish National registries, we identified 19 549 patients with a chronic heart failure diagnosis who had a measurement of potassium within minimum 90 days after initiated medical treatment with loop diuretics and angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers. All-cause mortality was examined according to eight predefined potassium levels: 2.8-3.4 mmol/L, 3.5-3.8 mmol/L, 3.9-4.1 mmol/L, 4.2-4.4 mmol/L, 4.5-4.7 mmol/L, 4.8-5.0 mmol/L, 5.1-5.5 mmol/L, and 5.6-7.4 mmol/L. Follow-up was 90 days from potassium measurement. We estimated the risk of all-cause mortality using multivariable adjusted Cox proportional hazard model, with normal serum potassium level at 4.2-4.4 mmol/L as reference. After 90 days, the mortality in the eight strata was 14.4, 8.0, 6.3, 5.0, 5.8, 7.9, 10.3, and 21.1{\%} respectively. In multivariable adjusted analysis, patients with potassium levels of 2.8-3.4 mmol/L [hazard ratio (HR): 3.16; confidence interval (CI): 2.43-4.11], 3.5-3.8 mmol/L (HR: 1.62; CI: 1.31-1.99), 3.9-4.1 mmol/L (HR: 1.29; CI: 1.08-1.55), 4.8-5.0 mmol/L (HR: 1.34; CI: 1.10-1.63), 5.1-5.5 mmol/L (HR: 1.60; CI: 1.29-1.97), and 5.6-7.4 mmol/L (HR: 3.31; CI: 2.61-4.20) had an increased risk of all-cause mortality.Conclusion: Levels within the lower and upper levels of the normal serum potassium range (3.5-4.1 mmol/L and 4.8-5.0 mmol/L, respectively) were associated with a significant increased short-term risk of death in chronic heart failure patients. Likewise, potassium below 3.5 mmol/L and above 5.0 mmol/L was also associated with increased mortality.",
keywords = "Journal Article",
author = "Mette Aldahl and Jensen, {Anne-Sofie Caroline} and Line Davidsen and Eriksen, {Matilde Alida} and {M{\o}ller Hansen}, Steen and Nielsen, {Berit Jamie} and Krogager, {Maria Luk{\'a}cs} and Lars K{\o}ber and Christian Torp-Pedersen and Peter S{\o}gaard",
year = "2017",
month = "10",
day = "7",
doi = "10.1093/eurheartj/ehx460",
language = "English",
volume = "38",
pages = "2890--2896",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "38",

}

RIS

TY - JOUR

T1 - Associations of serum potassium levels with mortality in chronic heart failure patients

AU - Aldahl, Mette

AU - Jensen, Anne-Sofie Caroline

AU - Davidsen, Line

AU - Eriksen, Matilde Alida

AU - Møller Hansen, Steen

AU - Nielsen, Berit Jamie

AU - Krogager, Maria Lukács

AU - Køber, Lars

AU - Torp-Pedersen, Christian

AU - Søgaard, Peter

PY - 2017/10/7

Y1 - 2017/10/7

N2 - Aims: Medication prescribed to patients suffering from chronic heart failure carries an increased risk of impaired potassium homeostasis. We examined the relation between different levels of serum potassium and mortality among patients with chronic heart failure.Methods and results: From Danish National registries, we identified 19 549 patients with a chronic heart failure diagnosis who had a measurement of potassium within minimum 90 days after initiated medical treatment with loop diuretics and angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers. All-cause mortality was examined according to eight predefined potassium levels: 2.8-3.4 mmol/L, 3.5-3.8 mmol/L, 3.9-4.1 mmol/L, 4.2-4.4 mmol/L, 4.5-4.7 mmol/L, 4.8-5.0 mmol/L, 5.1-5.5 mmol/L, and 5.6-7.4 mmol/L. Follow-up was 90 days from potassium measurement. We estimated the risk of all-cause mortality using multivariable adjusted Cox proportional hazard model, with normal serum potassium level at 4.2-4.4 mmol/L as reference. After 90 days, the mortality in the eight strata was 14.4, 8.0, 6.3, 5.0, 5.8, 7.9, 10.3, and 21.1% respectively. In multivariable adjusted analysis, patients with potassium levels of 2.8-3.4 mmol/L [hazard ratio (HR): 3.16; confidence interval (CI): 2.43-4.11], 3.5-3.8 mmol/L (HR: 1.62; CI: 1.31-1.99), 3.9-4.1 mmol/L (HR: 1.29; CI: 1.08-1.55), 4.8-5.0 mmol/L (HR: 1.34; CI: 1.10-1.63), 5.1-5.5 mmol/L (HR: 1.60; CI: 1.29-1.97), and 5.6-7.4 mmol/L (HR: 3.31; CI: 2.61-4.20) had an increased risk of all-cause mortality.Conclusion: Levels within the lower and upper levels of the normal serum potassium range (3.5-4.1 mmol/L and 4.8-5.0 mmol/L, respectively) were associated with a significant increased short-term risk of death in chronic heart failure patients. Likewise, potassium below 3.5 mmol/L and above 5.0 mmol/L was also associated with increased mortality.

AB - Aims: Medication prescribed to patients suffering from chronic heart failure carries an increased risk of impaired potassium homeostasis. We examined the relation between different levels of serum potassium and mortality among patients with chronic heart failure.Methods and results: From Danish National registries, we identified 19 549 patients with a chronic heart failure diagnosis who had a measurement of potassium within minimum 90 days after initiated medical treatment with loop diuretics and angiotensin converting enzyme inhibitors or angiotensin-II receptor blockers. All-cause mortality was examined according to eight predefined potassium levels: 2.8-3.4 mmol/L, 3.5-3.8 mmol/L, 3.9-4.1 mmol/L, 4.2-4.4 mmol/L, 4.5-4.7 mmol/L, 4.8-5.0 mmol/L, 5.1-5.5 mmol/L, and 5.6-7.4 mmol/L. Follow-up was 90 days from potassium measurement. We estimated the risk of all-cause mortality using multivariable adjusted Cox proportional hazard model, with normal serum potassium level at 4.2-4.4 mmol/L as reference. After 90 days, the mortality in the eight strata was 14.4, 8.0, 6.3, 5.0, 5.8, 7.9, 10.3, and 21.1% respectively. In multivariable adjusted analysis, patients with potassium levels of 2.8-3.4 mmol/L [hazard ratio (HR): 3.16; confidence interval (CI): 2.43-4.11], 3.5-3.8 mmol/L (HR: 1.62; CI: 1.31-1.99), 3.9-4.1 mmol/L (HR: 1.29; CI: 1.08-1.55), 4.8-5.0 mmol/L (HR: 1.34; CI: 1.10-1.63), 5.1-5.5 mmol/L (HR: 1.60; CI: 1.29-1.97), and 5.6-7.4 mmol/L (HR: 3.31; CI: 2.61-4.20) had an increased risk of all-cause mortality.Conclusion: Levels within the lower and upper levels of the normal serum potassium range (3.5-4.1 mmol/L and 4.8-5.0 mmol/L, respectively) were associated with a significant increased short-term risk of death in chronic heart failure patients. Likewise, potassium below 3.5 mmol/L and above 5.0 mmol/L was also associated with increased mortality.

KW - Journal Article

U2 - 10.1093/eurheartj/ehx460

DO - 10.1093/eurheartj/ehx460

M3 - Journal article

VL - 38

SP - 2890

EP - 2896

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 38

ER -

ID: 52617268