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Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain

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  • Carolina Donat-Vargas
  • Francisco Perez-Carrascosa
  • Celia Gomez-Peña
  • Vicente Mustieles
  • Inmaculada Salcedo-Bellido
  • Hanne Frederiksen
  • Agneta Åkesson
  • Juan Pedro Arrebola
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The general population is continuously exposed to phthalates via various consumer products. Epidemiological research relating phthalate exposure to thyroid function during non-developmental periods is limited. This study aimed to investigate the associations between specific serum phthalate metabolites and indicators of thyroid function in adults. We measured 10 serum phthalate metabolites and thyroid hormones - total triiodothyronine (TT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) - in a subsample of 207 adults from the GraMo cohort. This subsample was made up of men and women (in equal proportions) of middle age (49 ± 17 years) and from Southern Spain (province of Granada). Data on age, sex, body mass index, residence area, tobacco use, alcohol consumption and attained education were obtained from a questionnaire. Phthalate metabolites were log-transformed and categorized into tertiles. Cross-sectional associations of each metabolite with thyroid hormones were analyzed using multivariable-adjusted linear regression models. The mixture effect of metabolite phthalates was assessed using weighted quantile sum regression. After multivariable-adjustment, the following phthalate metabolites were significantly associated with TT3 in a dose-response manner: MMP (β = 0.90: 95% confidence interval 0.68,1.12), MEP (β = 0.67: 0.44, 0.90), MiBP (β = 0.49: 0.21, 0.77), MiDP (β = 0.27: 0.03, 0.52), MBzP (β = 0.51: 0.28, 0.73), MEHP (β = -0.59: -0.82, -0.35) and MiNP (β = -0.43: -0.71, -0.14), when comparing highest vs. lowest exposed. The sum of all metabolites was also linked to FT4 levels. No significant associations were observed for TSH except for MiNP. Although phthalate metabolites with different molecular weight showed opposite associations, overall metabolite concentrations seem to associate with increased TT3 and FT4 serum levels. The cross-sectional nature of this analysis limits causal inference.

Original languageEnglish
Article number117606
JournalEnvironmental pollution (Barking, Essex : 1987)
Volume287
Pages (from-to)117606
ISSN0269-7491
DOIs
Publication statusPublished - 15 Oct 2021

Bibliographical note

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

    Research areas

  • Adult, Aged, Cross-Sectional Studies, Environmental Exposure, Environmental Pollutants, Female, Humans, Male, Middle Aged, Phthalic Acids, Spain, Thyroid Hormones, Environmental epidemiology, Biological samples, Phthalates, Endocrine disrupting chemicals, Cohort study, Cross-sectional study, Thyroid hormones

ID: 67898391