TY - JOUR
T1 - Associations of lifestyle factors with amyloid pathology in persons without dementia
AU - Oomens, Julie E.
AU - Vos, Stephanie J.B.
AU - Maserejian, Nancy N.
AU - Boada, Mercè
AU - Didic, Mira
AU - Engelborghs, Sebastiaan
AU - Fladby, Tormod
AU - van der Flier, Wiesje M.
AU - Frisoni, Giovanni B.
AU - Fröhlich, Lutz
AU - Gill, Kiran Dip
AU - Grimmer, Timo
AU - Hort, Jakub
AU - Itoh, Yoshiaki
AU - Iwatsubo, Takeshi
AU - Klimkowicz-Mrowiec, Aleksandra
AU - Landau, Susan M.
AU - Lee, Dong Young
AU - Lleó, Alberto
AU - Martinez-Lage, Pablo
AU - de Mendonça, Alexandre
AU - Meyer, Philipp T.
AU - Parchi, Piero
AU - Pardini, Matteo
AU - Parnetti, Lucilla
AU - Popp, Julius
AU - Rami, Lorena
AU - Reiman, Eric M.
AU - Rinne, Juha O.
AU - Rodrigue, Karen M.
AU - Sánchez-Juan, Pascual
AU - Santana, Isabel
AU - Scarmeas, Nikolaos
AU - Scheltens, Philip
AU - Skoog, Ingmar
AU - Sperling, Reisa A.
AU - Stern, Yaakov
AU - Villeneuve, Sylvia
AU - Waldemar, Gunhild
AU - Wiltfang, Jens
AU - Zetterberg, Henrik
AU - Alcolea, Daniel
AU - Allegri, Ricardo F.
AU - Altomare, Daniele
AU - Bateman, Randall J.
AU - Baiardi, Simone
AU - Baldeiras, Ines
AU - Blennow, Kaj
AU - Braber, Anouk den
AU - van Buchem, Mark A.
AU - Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group
AU - for the Alzheimer's Disease Neuroimaging Initiative (ADNI)
AU - A4 Study group
AU - Dominantly Inherited Alzheimer Network (DIAN)
AU - European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI)
AU - Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE)
N1 - Publisher Copyright:
© The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
PY - 2025/12
Y1 - 2025/12
N2 - Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66–0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73–0.99, p = 0.029; OR = 0.62, 95%CI 0.45–0.86, p = 0.004). Conclusions: In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.
AB - Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from the Amyloid Biomarker Study data pooling initiative. We used generalized estimating equations to assess associations of dichotomized lifestyle measures with amyloid pathology. Results: We included 9171 participants with normal cognition (NC) and 2555 participants with mild cognitive impairment (MCI) from the Amyloid Biomarker Study. Of participants with NC, 58% were women, 34% were APOE ε4 carrier, and 27% had amyloid pathology. Of participants with MCI, 48% were women, 47% were APOE ε4 carrier, and 57% had amyloid pathology. In NC, cognitively active participants were less likely to have amyloid pathology (OR = 0.77, 95%CI 0.66–0.89, p < 0.001). In MCI, participants who had ever smoked or had sleep problems were less likely to have amyloid pathology (OR = 0.85, 95%CI 0.73–0.99, p = 0.029; OR = 0.62, 95%CI 0.45–0.86, p = 0.004). Conclusions: In NC, cognitive activity was associated with a lower frequency of amyloid pathology. In MCI, favorable lifestyle behaviors were not associated with a lower frequency of amyloid pathology. The results of the current study contribute to the broader evidence base on lifestyle and AD by further characterizing the role of lifestyle behaviors in AD pathology across different clinical stages.
KW - Alzheimer's disease
KW - amyloid
KW - amyloid biomarker study
KW - cerebrospinal fluid
KW - lifestyle
KW - positron emission tomography
UR - https://www.scopus.com/pages/publications/105023169506
U2 - 10.1177/13872877251379083
DO - 10.1177/13872877251379083
M3 - Journal article
C2 - 41234025
AN - SCOPUS:105023169506
SN - 1387-2877
VL - 108
SP - 1043
EP - 1059
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -