Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Associations between oxidative stress and perceived stress in patients with bipolar disorder and healthy control individuals

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Stability of admission diagnoses; data from a specialized in-patient treatment facility for dual diagnosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of ketogenic diets in the treatment of central nervous system diseases: a systematic review

    Research output: Contribution to journalReviewpeer-review

  3. Level of alexithymia as a measure of personality dysfunction in avoidant personality disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mortality among male forensic and non-forensic psychiatric patients: Matched cohort study of rates, predictors and causes-of-death

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Internet-based therapy with FearFighter for anxiety disorders: a randomised clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: Patients with neurodegenerative disorders, schizophrenia, and bipolar disorder present with increased oxidative stress markers. Not only is oxidative stress associated with development of disease, but also with increased disease progression and mortality. Oxidative stress reflects an increase in pro-oxidants, which subsequently leads to oxidative modifications of cellular components, such as RNA and DNA. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the valid marker of whole-body RNA and DNA damage, respectively. Recently, cerebrospinal fluid (CSF) oxidative stress markers of RNA damage (8-oxoGuo) have showed both state and trait dependence in patients with bipolar disorder. However, the relation to subjective measures of stress and quality of life (QoL) is unknown.

MATERIALS AND METHODS: This prospective, longitudinal 1-year follow-up case-control study investigated the association between the oxidative stress markers, 8-oxoGuo and 8-oxodG and, perceived stress and QoL in patients with bipolar disorder (n = 86, 51% female) and gender-and-age-matched healthy control (HC) individuals (n = 44, 44% female). Oxidative stress markers obtained in CSF and urine were analysed using ultra-performance liquid chromatography-tandem mass spectrometry. The subjective perception of stress was assessed using the Perceived Stress Scale. Subjective evaluation of QoL was assessed using the World Health Organization Quality of Life questionnaire.

RESULTS AND CONCLUSION: We found that markers of oxidative stress in CSF and urine were not associated with perceived stress and QoL quality in patients with bipolar disorder. However, a putative association between urinary 8-oxoGuo oxidative stress marker for RNA damage and perceived stress in HC encourages further investigations.

Original languageEnglish
JournalNordic Journal of Psychiatry
Pages (from-to)1-6
Number of pages6
ISSN0803-9488
DOIs
Publication statusE-pub ahead of print - 29 Mar 2021

ID: 64729552