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Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

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Derkach, A, Otim, I, Pfeiffer, RM, Onabajo, OO, Legason, ID, Nabalende, H, Ogwang, MD, Kerchan, P, Talisuna, AO, Ayers, LW, Reynolds, SJ, Nkrumah, F, Neequaye, J, Bhatia, K, Theander, TG, Prokunina-Olsson, L, Turner, L, Goedert, JJ, Lavstsen, T & Mbulaiteye, SM 2019, 'Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies' EBioMedicine, vol. 39, pp. 358-368. https://doi.org/10.1016/j.ebiom.2018.12.020

APA

CBE

Derkach A, Otim I, Pfeiffer RM, Onabajo OO, Legason ID, Nabalende H, Ogwang MD, Kerchan P, Talisuna AO, Ayers LW, Reynolds SJ, Nkrumah F, Neequaye J, Bhatia K, Theander TG, Prokunina-Olsson L, Turner L, Goedert JJ, Lavstsen T, Mbulaiteye SM. 2019. Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies. EBioMedicine. 39:358-368. https://doi.org/10.1016/j.ebiom.2018.12.020

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Author

Derkach, Andriy ; Otim, Isaac ; Pfeiffer, Ruth M ; Onabajo, Olusegun O ; Legason, Ismail D ; Nabalende, Hadijah ; Ogwang, Martin D ; Kerchan, Patrick ; Talisuna, Ambrose O ; Ayers, Leona W ; Reynolds, Steven J ; Nkrumah, Francis ; Neequaye, Janet ; Bhatia, Kishor ; Theander, Thor G ; Prokunina-Olsson, Ludmila ; Turner, Louise ; Goedert, James J ; Lavstsen, Thomas ; Mbulaiteye, Sam M. / Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies. In: EBioMedicine. 2019 ; Vol. 39. pp. 358-368.

Bibtex

@article{1e379d6b86424396a765d7e0ce4d2fc4,
title = "Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies",
abstract = "BACKGROUND: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria.METHODS: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Adjusted odds ratios (aORs) for case-control associations were estimated by logistic regression.FINDINGS: There was stronger reactivity to the severe malaria associated CIDRα1 domains than other CIDR domains both in cases and controls. eBL cases reacted to fewer antigens than controls (Ghana: p = 0·001; Uganda: p = 0·03), with statistically significant lower ORs associated with reactivity to 13+ antigens in Ghana (aOR 0·39, 95{\%} CI 0·24-0·63; pheterogeneity = 0·00011) and Uganda (aOR 0·60, 95{\%} CI 0.41-0·88; pheterogeneity = 0·008). eBL was inversely associated with reactivity, coded as quartiles, to group A variant CIDRδ1 (ptrend = 0·035) in Ghana and group B CD36-binding variants CIDRα2·2 (ptrend = 0·006) and CIDRα2·4 (ptrend = 0·033) in Uganda, and positively associated with reactivity to SERA5 in Ghana (ptrend = 0·017) and Uganda (ptrend = 0·007) and group A CIDRα1·5 variant in Uganda only (ptrend = 0·034).INTERPRETATION: eBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk.FUNDING: Intramural Research Program, National Cancer Institute and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services.",
keywords = "Adolescent, Antibodies, Protozoan/metabolism, Binding Sites, Burkitt Lymphoma/immunology, Case-Control Studies, Child, Child, Preschool, Female, Ghana, Humans, Immunoglobulin G/metabolism, Infant, Infant, Newborn, Logistic Models, Malaria, Falciparum/immunology, Male, Odds Ratio, Plasmodium falciparum/immunology, Protozoan Proteins/chemistry, Uganda",
author = "Andriy Derkach and Isaac Otim and Pfeiffer, {Ruth M} and Onabajo, {Olusegun O} and Legason, {Ismail D} and Hadijah Nabalende and Ogwang, {Martin D} and Patrick Kerchan and Talisuna, {Ambrose O} and Ayers, {Leona W} and Reynolds, {Steven J} and Francis Nkrumah and Janet Neequaye and Kishor Bhatia and Theander, {Thor G} and Ludmila Prokunina-Olsson and Louise Turner and Goedert, {James J} and Thomas Lavstsen and Mbulaiteye, {Sam M}",
note = "Published by Elsevier B.V.",
year = "2019",
month = "1",
doi = "10.1016/j.ebiom.2018.12.020",
language = "English",
volume = "39",
pages = "358--368",
journal = "EBioMedicine",
issn = "2352-3964",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies

AU - Derkach, Andriy

AU - Otim, Isaac

AU - Pfeiffer, Ruth M

AU - Onabajo, Olusegun O

AU - Legason, Ismail D

AU - Nabalende, Hadijah

AU - Ogwang, Martin D

AU - Kerchan, Patrick

AU - Talisuna, Ambrose O

AU - Ayers, Leona W

AU - Reynolds, Steven J

AU - Nkrumah, Francis

AU - Neequaye, Janet

AU - Bhatia, Kishor

AU - Theander, Thor G

AU - Prokunina-Olsson, Ludmila

AU - Turner, Louise

AU - Goedert, James J

AU - Lavstsen, Thomas

AU - Mbulaiteye, Sam M

N1 - Published by Elsevier B.V.

PY - 2019/1

Y1 - 2019/1

N2 - BACKGROUND: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria.METHODS: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Adjusted odds ratios (aORs) for case-control associations were estimated by logistic regression.FINDINGS: There was stronger reactivity to the severe malaria associated CIDRα1 domains than other CIDR domains both in cases and controls. eBL cases reacted to fewer antigens than controls (Ghana: p = 0·001; Uganda: p = 0·03), with statistically significant lower ORs associated with reactivity to 13+ antigens in Ghana (aOR 0·39, 95% CI 0·24-0·63; pheterogeneity = 0·00011) and Uganda (aOR 0·60, 95% CI 0.41-0·88; pheterogeneity = 0·008). eBL was inversely associated with reactivity, coded as quartiles, to group A variant CIDRδ1 (ptrend = 0·035) in Ghana and group B CD36-binding variants CIDRα2·2 (ptrend = 0·006) and CIDRα2·4 (ptrend = 0·033) in Uganda, and positively associated with reactivity to SERA5 in Ghana (ptrend = 0·017) and Uganda (ptrend = 0·007) and group A CIDRα1·5 variant in Uganda only (ptrend = 0·034).INTERPRETATION: eBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk.FUNDING: Intramural Research Program, National Cancer Institute and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services.

AB - BACKGROUND: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria.METHODS: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Adjusted odds ratios (aORs) for case-control associations were estimated by logistic regression.FINDINGS: There was stronger reactivity to the severe malaria associated CIDRα1 domains than other CIDR domains both in cases and controls. eBL cases reacted to fewer antigens than controls (Ghana: p = 0·001; Uganda: p = 0·03), with statistically significant lower ORs associated with reactivity to 13+ antigens in Ghana (aOR 0·39, 95% CI 0·24-0·63; pheterogeneity = 0·00011) and Uganda (aOR 0·60, 95% CI 0.41-0·88; pheterogeneity = 0·008). eBL was inversely associated with reactivity, coded as quartiles, to group A variant CIDRδ1 (ptrend = 0·035) in Ghana and group B CD36-binding variants CIDRα2·2 (ptrend = 0·006) and CIDRα2·4 (ptrend = 0·033) in Uganda, and positively associated with reactivity to SERA5 in Ghana (ptrend = 0·017) and Uganda (ptrend = 0·007) and group A CIDRα1·5 variant in Uganda only (ptrend = 0·034).INTERPRETATION: eBL cases reacted to fewer antigens than controls using samples from two populations, Ghana and Uganda. Attenuated humoral immunity to Pf EMP1 may contribute to susceptibility to low-grade malaria and eBL risk.FUNDING: Intramural Research Program, National Cancer Institute and National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services.

KW - Adolescent

KW - Antibodies, Protozoan/metabolism

KW - Binding Sites

KW - Burkitt Lymphoma/immunology

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Female

KW - Ghana

KW - Humans

KW - Immunoglobulin G/metabolism

KW - Infant

KW - Infant, Newborn

KW - Logistic Models

KW - Malaria, Falciparum/immunology

KW - Male

KW - Odds Ratio

KW - Plasmodium falciparum/immunology

KW - Protozoan Proteins/chemistry

KW - Uganda

U2 - 10.1016/j.ebiom.2018.12.020

DO - 10.1016/j.ebiom.2018.12.020

M3 - Journal article

VL - 39

SP - 358

EP - 368

JO - EBioMedicine

JF - EBioMedicine

SN - 2352-3964

ER -

ID: 59239595