Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Associations between electroencephalography power and Alzheimer's disease in persons with Down syndrome

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Broad consent for biobanks is best - provided it is also deep

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Determining Filipino Normative Data for a Battery of Neuropsychological Tests: The Filipino Norming Project (FNP)

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Oscillatory connectivity as a diagnostic marker of dementia due to Alzheimer's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Psychogenic nonepileptic seizures treated with psychotherapy: Long-term outcome on seizures and healthcare utilization

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Declining malformation rates with changed antiepileptic drug prescribing: An observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: It is complicated to diagnose dementia in persons with Down syndrome (DS). Older studies have, however, demonstrated low-frequency activity in electroencephalography (EEG) in persons with concurrent DS and Alzheimer's disease (DS-AD). The aim of this study was to examine whether it was possible to identify AD-associated changes (increased high-frequency power and decreased low-frequency power) in persons with DS-AD compared with DS.

METHODS: We included 21 persons with DS-AD and 16 with DS without cognitive deterioration assessed by the informant-based Dementia Screening Questionnaire in Intellectual Disability. EEG was recorded for all participants. Absolute power for each electrode and global power were calculated for all frequency bands for both eyes open and eyes closed.

RESULTS: For global power in the eyes closed condition, we found an increased global slow-frequency activity and a decreased global high-frequency activity in DS-AD compared with DS. In addition, we found a significant difference in the global alpha/delta ratio with the largest difference found for global alpha power in DS-AD compared with DS.

CONCLUSIONS: In the current study, we found that changes known to be associated with AD could also be identified when comparing DS-AD with DS using quantitative EEG. In general, these findings suggest that EEG might be a useful tool in diagnosing AD in persons with DS, but larger studies are needed.

Original languageEnglish
JournalJournal of intellectual disability research : JIDR
Volume63
Issue number9
Pages (from-to)1151-1157
Number of pages7
ISSN0964-2633
DOIs
Publication statusPublished - Sep 2019

ID: 58170575