Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Associations between body mass index and height during childhood and adolescence and the risk of coronary heart disease in adulthood: A systematic review and meta-analysis

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. A vicious circle in chronic lymphoedema pathophysiology? An adipocentric view

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Does stress influence sleep patterns, food intake, weight gain, abdominal obesity and weight loss interventions and vice versa?

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Instrumental variable analysis using offspring BMI in childhood as an indicator of parental BMI in relation to mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association of Childhood Fat Mass and Weight With Adult-Onset Type 2 Diabetes in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Birthweight, Childhood Body Mass Index, Height and Growth, and Risk of Polycystic Ovary Syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Body mass index (BMI) at child and adolescent ages is positively associated with adult coronary heart disease (CHD) whereas height at these ages may be inversely associated with CHD. However, potential effects of age, sex, and socioeconomic status on associations between BMI and CHD are less investigated. We conducted a systematic review and meta-analysis of BMI and height at ages 2-19 years in relation to adult CHD and examined effects of age, sex, socioeconomic status, and other factors. Twenty-two studies on BMI and five on height were included, comprising 5,538,319 individuals and 69,830 CHD events. Random effects meta-analyses were conducted. Child and adolescent BMI were positively associated with CHD (hazard ratio = 1.12; 95% confidence interval [CI] [1.01, 1.25] per standard deviation [SD]), and categorical analyses supported these findings. The associations did not significantly differ by age, sex, or by adjustment for socioeconomic status. Child and adolescent height were inversely associated with CHD (hazard ratio = 0.87; 95% CI [0.81, 0.93] per SD), and categorical analyses agreed. Insufficient studies on height precluded subgroup analyses. Heterogeneity was generally high in all analyses. We found that BMI in youth is positively associated with adult CHD regardless of sex or adjustment for socioeconomic status whereas height is inversely associated with later risk of CHD.

Original languageEnglish
Article numbere13276
JournalObesity reviews : an official journal of the International Association for the Study of Obesity
Volume22
Issue number9
Pages (from-to)e13276
ISSN1467-7881
DOIs
Publication statusPublished - Sep 2021

ID: 66432663