TY - JOUR
T1 - Associations between Albuminuria, Estimated GFR and Cardiac Phenotype in a Cohort with Chronic Kidney Disease - The CPH-CKD ECHO Study
AU - Landler, Nino Emanuel
AU - Olsen, Flemming Javier
AU - Christensen, Jacob
AU - Bro, Susanne
AU - Feldt-Rasmussen, Bo
AU - Hansen, Ditte
AU - Kamper, Anne-Lise
AU - Christoffersen, Christina
AU - Ballegaard, Ellen Linnea Freese
AU - Sørensen, Ida Maria Hjelm
AU - Bjergfelt, Sasha Saurbrey
AU - Seidelin, Eline
AU - Gislason, Gunnar
AU - Biering-Sørensen, Tor
N1 - Copyright © 2022. Published by Elsevier Inc.
PY - 2022/11
Y1 - 2022/11
N2 - OBJECTIVE: Echocardiographic findings in chronic kidney disease (CKD) vary. We sought to estimate the prevalence of abnormal cardiac structure and function in patients with CKD and their association to estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR).METHODS: We prospectively enrolled 825 outpatients with non-dialysis-dependent CKD, mean age 58± 13 yrs, and 175 matched healthy controls, mean age 60±12 yrs. Echocardiography included assessment of left ventricular (LV) hypertrophy, LV ejection fraction (LVEF), global longitudinal strain (GLS) and diastolic dysfunction according to ASE/EACVI guidelines.RESULTS: LV hypertrophy was found in 9% of patients vs. 1.7% of controls (p=0.005) was independently associated with UACR (p=0.002). Median LVEF was 59.4% (IQR 55.2, 62.8) in patients vs. 60.8% (57.7, 64.1) in controls (p=0.002). GLS was decreased in patients with eGFR <60ml/min/1.73m² (-17.6%±3.1%) vs. patients with higher eGFR (19.0%±2.2%, p<0.001), who were similar to controls. . Diastolic dysfunction was detected in 55% of patients and in 34% of controls.LIMITATIONS: Non-random sampling, cross-sectional analysis.CONCLUSIONS: We report lower prevalence of hypertrophy than previous studies, but similar measurements of systolic and diastolic function. Cardiac remodeling in CKD may be influenced by treatment modalities, demographics, comorbidities and renal pathology.
AB - OBJECTIVE: Echocardiographic findings in chronic kidney disease (CKD) vary. We sought to estimate the prevalence of abnormal cardiac structure and function in patients with CKD and their association to estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (UACR).METHODS: We prospectively enrolled 825 outpatients with non-dialysis-dependent CKD, mean age 58± 13 yrs, and 175 matched healthy controls, mean age 60±12 yrs. Echocardiography included assessment of left ventricular (LV) hypertrophy, LV ejection fraction (LVEF), global longitudinal strain (GLS) and diastolic dysfunction according to ASE/EACVI guidelines.RESULTS: LV hypertrophy was found in 9% of patients vs. 1.7% of controls (p=0.005) was independently associated with UACR (p=0.002). Median LVEF was 59.4% (IQR 55.2, 62.8) in patients vs. 60.8% (57.7, 64.1) in controls (p=0.002). GLS was decreased in patients with eGFR <60ml/min/1.73m² (-17.6%±3.1%) vs. patients with higher eGFR (19.0%±2.2%, p<0.001), who were similar to controls. . Diastolic dysfunction was detected in 55% of patients and in 34% of controls.LIMITATIONS: Non-random sampling, cross-sectional analysis.CONCLUSIONS: We report lower prevalence of hypertrophy than previous studies, but similar measurements of systolic and diastolic function. Cardiac remodeling in CKD may be influenced by treatment modalities, demographics, comorbidities and renal pathology.
KW - Albuminuria/diagnosis
KW - Cross-Sectional Studies
KW - Glomerular Filtration Rate
KW - Heart Failure/complications
KW - Humans
KW - Hypertrophy, Left Ventricular/diagnostic imaging
KW - Phenotype
KW - Renal Insufficiency, Chronic/diagnosis
KW - Ventricular Dysfunction, Left/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85139737975&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2022.09.002
DO - 10.1016/j.cardfail.2022.09.002
M3 - Journal article
C2 - 36126901
VL - 28
SP - 1615
EP - 1627
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
SN - 1071-9164
IS - 11
ER -