Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer

Christina Annette Bjerre; Ann Knoop; Karsten Bjerre; Mathilde S Larsen; Katrine L Henriksen; Maria Bibi Lyng; Henrik Jørn Ditzel; Birgitte B Rasmussen; Nils Aage Brünner; Bent Ejlertsen; Anne-Vibeke Laenkholm

doi:10.3109/0284186X.2012.734922

Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer

Christina Annette Bjerre, Ann Knoop, Karsten Bjerre, Mathilde S Larsen, Katrine L Henriksen, Maria Bibi Lyng, Henrik Jørn Ditzel, Birgitte B Rasmussen, Nils Aage Brünner, Bent Ejlertsen, Anne-Vibeke Laenkholm

14 Citations (Scopus)

Abstract

The role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in estrogen receptor (ER) positive breast cancer remains to be fully elucidated. We evaluated TIMP-1 as a prognostic marker in patients treated with adjuvant tamoxifen and investigated TIMP-1s association with Ki67 and ER/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) profiles.

Original language	English
Journal	Acta oncologica
Volume	52
Issue number	1
Pages (from-to)	82-90
Number of pages	9
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186X.2012.734922
Publication status	Published - Jan 2013

Keywords

Aged
Antineoplastic Agents, Hormonal
Breast Neoplasms
Cohort Studies
Female
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
Ki-67 Antigen
Middle Aged
Multivariate Analysis
Prognosis
Receptor, erbB-2
Receptors, Estrogen
Receptors, Progesterone
Tamoxifen
Tissue Inhibitor of Metalloproteinase-1

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10.3109/0284186X.2012.734922

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title = "Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer",

abstract = "The role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in estrogen receptor (ER) positive breast cancer remains to be fully elucidated. We evaluated TIMP-1 as a prognostic marker in patients treated with adjuvant tamoxifen and investigated TIMP-1s association with Ki67 and ER/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) profiles.",

keywords = "Aged, Antineoplastic Agents, Hormonal, Breast Neoplasms, Cohort Studies, Female, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kaplan-Meier Estimate, Ki-67 Antigen, Middle Aged, Multivariate Analysis, Prognosis, Receptor, erbB-2, Receptors, Estrogen, Receptors, Progesterone, Tamoxifen, Tissue Inhibitor of Metalloproteinase-1",

author = "Bjerre, \{Christina Annette\} and Ann Knoop and Karsten Bjerre and Larsen, \{Mathilde S\} and Henriksen, \{Katrine L\} and Lyng, \{Maria Bibi\} and Ditzel, \{Henrik J{\o}rn\} and Rasmussen, \{Birgitte B\} and Br{\"u}nner, \{Nils Aage\} and Bent Ejlertsen and Anne-Vibeke Laenkholm",

year = "2013",

month = jan,

doi = "10.3109/0284186X.2012.734922",

language = "English",

volume = "52",

pages = "82--90",

journal = "Acta oncologica ",

issn = "0284-186X",

publisher = "Medical Journals Sweden AB",

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TY - JOUR

T1 - Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer

AU - Bjerre, Christina Annette

AU - Knoop, Ann

AU - Bjerre, Karsten

AU - Larsen, Mathilde S

AU - Henriksen, Katrine L

AU - Lyng, Maria Bibi

AU - Ditzel, Henrik Jørn

AU - Rasmussen, Birgitte B

AU - Brünner, Nils Aage

AU - Ejlertsen, Bent

AU - Laenkholm, Anne-Vibeke

PY - 2013/1

Y1 - 2013/1

N2 - The role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in estrogen receptor (ER) positive breast cancer remains to be fully elucidated. We evaluated TIMP-1 as a prognostic marker in patients treated with adjuvant tamoxifen and investigated TIMP-1s association with Ki67 and ER/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) profiles.

AB - The role of tissue inhibitor of metalloproteinases-1 (TIMP-1) in estrogen receptor (ER) positive breast cancer remains to be fully elucidated. We evaluated TIMP-1 as a prognostic marker in patients treated with adjuvant tamoxifen and investigated TIMP-1s association with Ki67 and ER/progesterone receptor (PR)/human epidermal growth factor receptor 2 (HER2) profiles.

KW - Aged

KW - Antineoplastic Agents, Hormonal

KW - Breast Neoplasms

KW - Cohort Studies

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization, Fluorescence

KW - Kaplan-Meier Estimate

KW - Ki-67 Antigen

KW - Middle Aged

KW - Multivariate Analysis

KW - Prognosis

KW - Receptor, erbB-2

KW - Receptors, Estrogen

KW - Receptors, Progesterone

KW - Tamoxifen

KW - Tissue Inhibitor of Metalloproteinase-1

UR - https://www.scopus.com/pages/publications/84871415828

U2 - 10.3109/0284186X.2012.734922

DO - 10.3109/0284186X.2012.734922

M3 - Journal article

C2 - 23205744

SN - 0284-186X

VL - 52

SP - 82

EP - 90

JO - Acta oncologica

JF - Acta oncologica

IS - 1

ER -

Association of tissue inhibitor of metalloproteinases-1 and Ki67 in estrogen receptor positive breast cancer

Abstract

Keywords

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