Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

Martin Blomberg Jensen; H Leffers; J H Petersen; G Daugaard; N E Skakkebaek; E Rajpert-De Meyts

doi:10.1093/annonc/mdn407

Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

Martin Blomberg Jensen, H Leffers, J H Petersen, G Daugaard, N E Skakkebaek, E Rajpert-De Meyts

Department of Growth and Reproduction

25 Citations (Scopus)

Abstract

A possible association between the polymorphic CAG repeat in the DNA polymerase gamma (POLG) gene and the risk of testicular germ-cell tumours (TGCT) was investigated in this study. The hypothesis was prompted by an earlier preliminary study proposing an association of the absence of the common 10-CAG-long POLG allele with testicular cancer as well as previously reported in some European populations' association with male subfertility, which is a condition carrying an increased risk of TGCT.

Original language	English
Journal	Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Volume	19
Issue number	11
Pages (from-to)	1910-4
Number of pages	5
ISSN	0923-7534
DOIs	https://doi.org/10.1093/annonc/mdn407
Publication status	Published - Nov 2008

Keywords

Adult
Alleles
Case-Control Studies
DNA-Directed DNA Polymerase
Genotype
Humans
Male
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal
Polymorphism, Genetic
Testicular Neoplasms
Trinucleotide Repeats

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Jensen, M. B., Leffers, H., Petersen, J. H., Daugaard, G., Skakkebaek, N. E., & Rajpert-De Meyts, E. (2008). Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 19(11), 1910-4. https://doi.org/10.1093/annonc/mdn407

Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer. / Jensen, Martin Blomberg ; Leffers, H ; Petersen, J H et al.
In: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 19, No. 11, 11.2008, p. 1910-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Jensen, MB , Leffers, H , Petersen, JH , Daugaard, G , Skakkebaek, NE & Rajpert-De Meyts, E 2008, 'Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer', Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, vol. 19, no. 11, pp. 1910-4. https://doi.org/10.1093/annonc/mdn407

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KW - Case-Control Studies

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KW - Neoplasm Staging

KW - Neoplasms, Germ Cell and Embryonal

KW - Polymorphism, Genetic

KW - Testicular Neoplasms

KW - Trinucleotide Repeats

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Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ-cell cancer

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Keywords

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