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Association of soluble urokinase plasminogen activator receptor levels with fibrotic and vascular manifestations in systemic sclerosis

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  1. Reward signalling in brainstem nuclei under fluctuating blood glucose

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  2. Experiences managing pregnant hospital staff members using an active management policy-A qualitative study

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  3. A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19

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  4. Histological outcomes in HPV-screened elderly women in Denmark

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  5. Prevalence of MRSA nasal carriage among pregnant women in Copenhagen

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  1. Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study

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  2. Cardiovascular comorbidities as predictors for severe COVID-19 infection or death

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  3. An open label trial of anakinra to prevent respiratory failure in COVID-19

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  4. Association Between Elevated suPAR, a New Biomarker of Inflammation, and Accelerated Aging

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OBJECTIVE: We assessed the association of suPAR (soluble urokinase plasminogen activator receptor) plasma levels with fibrotic and vascular manifestations in patients with systemic sclerosis (SSc).

METHODS: suPAR plasma levels were measured in 121 consecutive patients with SSc and correlated to pulmonary and vascular features of SSc, including interstitial lung disease as characterized by percentage of predicted CO diffusing capacity (DLco) and forced vital capacity (FVC), pulmonary fibrosis by computed tomography, and pulmonary arterial hypertension, telangiectasias, and digital ulcers.

RESULTS: Overall, 121 SSc patients (84% females; mean age, 57 ± 12 [range: 22-79] years) were enrolled; 35% had diffuse cutaneous SSc. suPAR plasma levels ranged from 1.3-10.2 [median: 2.9 (p25-p75: 2.3-3.9)] ng/mL. Log(suPAR) levels correlated with DLco (r = -0.41, p <0.0001) and FVC (r = -0.26, p = 0.004), also when adjusted for age, sex, and pulmonary hypertension. A suPAR cut-off level of >2.5 ng/mL showed a sensitivity of 91% for identifying patients with either DLco <50% or FVC < 60% of the predicted values. Similarly, 19 (90%) had a suPAR >2.5 ng/mL among those diagnosed with pulmonary fibrosis vs. 59 (60%) among those who did not (p = 0.008). suPAR values were not associated with vascular manifestations.

CONCLUSION: suPAR levels strongly correlated with pulmonary involvement in SSc. Future studies should test if suPAR estimation can be used for surveillance of severe pulmonary involvement in SSc.

Original languageEnglish
JournalPLoS One
Volume16
Issue number2
Pages (from-to)e0247256
ISSN1932-6203
DOIs
Publication statusPublished - 22 Feb 2021

ID: 62392494