Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania

Research output: Contribution to journalJournal articlepeer-review


  1. Dynamics of a Staphylococcus aureus infective endocarditis simulation model

    Research output: Contribution to journalJournal articlepeer-review

  2. Endotracheal lactate reflects lower respiratory tract infections and inflammation in intubated patients

    Research output: Contribution to journalJournal articlepeer-review

  3. Gastrointestinal dysbiosis and Escherichia coli pathobionts in inflammatory bowel diseases

    Research output: Contribution to journalEditorialpeer-review

View graph of relations

This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naive and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR = 1.82, CI: 1.10, 3.01, p = 0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.

Original languageEnglish
Article number13214
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Issue number4
Pages (from-to)230-239
Number of pages10
Publication statusPublished - Apr 2022

Bibliographical note

This article is protected by copyright. All rights reserved.

    Research areas

  • antiretroviral therapy, HIV, Sickle cell trait, β-cell dysfunction and physical activity

ID: 74471507