Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

Leon J S Brokken; Yvonne Lundberg-Giwercman; Ewa Rajpert-De Meyts; Jakob Eberhard; Olof Ståhl; Gabriella Cohn-Cedermark; Gedske Daugaard; Stefan Arver; Aleksander Giwercman

doi:10.1016/j.mce.2011.12.018

Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

Leon J S Brokken, Yvonne Lundberg-Giwercman, Ewa Rajpert-De Meyts, Jakob Eberhard, Olof Ståhl, Gabriella Cohn-Cedermark, Gedske Daugaard, Stefan Arver, Aleksander Giwercman

Department of Growth and Reproduction

24 Citations (Scopus)

Abstract

Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.

Original language	English
Journal	Molecular and Cellular Endocrinology
Volume	351
Pages (from-to)	279-285
Number of pages	7
ISSN	0303-7207
DOIs	https://doi.org/10.1016/j.mce.2011.12.018
Publication status	Published - 2012

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Brokken, L. J. S., Lundberg-Giwercman, Y., Rajpert-De Meyts, E., Eberhard, J., Ståhl, O., Cohn-Cedermark, G., Daugaard, G., Arver, S., & Giwercman, A. (2012). Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. Molecular and Cellular Endocrinology, 351, 279-285. https://doi.org/10.1016/j.mce.2011.12.018

Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer. / Brokken, Leon J S; Lundberg-Giwercman, Yvonne; Rajpert-De Meyts, Ewa et al.
In: Molecular and Cellular Endocrinology, Vol. 351, 2012, p. 279-285.

Research output: Contribution to journal › Journal article › Research › peer-review

Brokken, LJS, Lundberg-Giwercman, Y, Rajpert-De Meyts, E, Eberhard, J, Ståhl, O, Cohn-Cedermark, G, Daugaard, G, Arver, S & Giwercman, A 2012, 'Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer', Molecular and Cellular Endocrinology, vol. 351, pp. 279-285. https://doi.org/10.1016/j.mce.2011.12.018

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title = "Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer",

abstract = "Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95\% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95\% CI: 0.51-0.89, and rs4953617; OR=1.88, 95\% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95\% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95\% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.",

author = "Brokken, \{Leon J S\} and Yvonne Lundberg-Giwercman and \{Rajpert-De Meyts\}, Ewa and Jakob Eberhard and Olof St{\aa}hl and Gabriella Cohn-Cedermark and Gedske Daugaard and Stefan Arver and Aleksander Giwercman",

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doi = "10.1016/j.mce.2011.12.018",

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T1 - Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

AU - Brokken, Leon J S

AU - Lundberg-Giwercman, Yvonne

AU - Rajpert-De Meyts, Ewa

AU - Eberhard, Jakob

AU - Ståhl, Olof

AU - Cohn-Cedermark, Gabriella

AU - Daugaard, Gedske

AU - Arver, Stefan

AU - Giwercman, Aleksander

PY - 2012

Y1 - 2012

N2 - Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.

AB - Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.

UR - https://www.scopus.com/pages/publications/84857138660

U2 - 10.1016/j.mce.2011.12.018

DO - 10.1016/j.mce.2011.12.018

M3 - Journal article

C2 - 22245602

SN - 0303-7207

VL - 351

SP - 279

EP - 285

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

ER -

Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer

Abstract

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