Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Responsiveness of clinical tests for people with neck pain

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Bone shortening of clavicular fractures: comparison of measurement methods

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Changes in clavicle length in acute fractures within 3 weeks: a prospective ultrasonographic study of 59 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Pure exercise intolerance and ophthalmoplegia associated with the m.12,294G > A mutation in the MT-TL2 gene: a case report

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Infographic. Exercise therapy for meniscal tears: evidence and recommendations

    Research output: Contribution to journalComment/debateResearchpeer-review

  2. Prevalence of depressive disorder among patients with fibromyalgia: Systematic review and meta-analysis

    Research output: Contribution to journalReviewResearchpeer-review

  3. Perioperative alcohol cessation intervention for postoperative complications

    Research output: Contribution to journalReviewResearchpeer-review

  • Joyce A C van Tunen
  • Andrea Dell'Isola
  • Carsten Juhl
  • Joost Dekker
  • Martijn Steultjens
  • Jonas B Thorlund
  • Hans Lund
View graph of relations

BACKGROUND: To investigate (1) the association of specific biomechanical factors with knee osteoarthritis and knee osteoarthritis development, and (2) the impact of other relevant risk factors on this association.

METHODS: MEDLINE, EMBASE, CINAHL and SPORTDiscus were searched up until April 2017. Studies were included if they fulfilled the following criteria: the study 1) assessed the association of a biomechanical factor with knee osteoarthritis, or knee osteoarthritis development; 2) reported on skeletal malalignment, muscular dysfunction, impaired proprioception, laxity and abnormal loading during gait; 3) was a cohort study with participants developing knee osteoarthritis and participants not developing knee osteoarthritis, or a case-control or cross-sectional study with participants with knee osteoarthritis and without knee osteoarthritis. Risk of bias was assessed with the QUIPS tool and meta-analyses were performed using random effects models.

RESULTS: Of 6413 unique studies identified, 59 cross-sectional studies were eligible for meta-analyses (9825 participants, 5328 with knee osteoarthritis). No cohort studies fulfilled the inclusion criteria. Compared with healthy controls, patients with knee osteoarthritis have higher odds of having lower muscle strength, proprioception deficits, more medial varus-valgus laxity and less lateral varus-valgus laxity. Patients with medial knee osteoarthritis have higher odds of having a higher knee adduction moment than healthy controls. Level of evidence was graded as 'very low' to 'moderate' quality. Due to large between study differences moderation of other risk factors on biomechanical risk factors could not be evaluated.

CONCLUSIONS: Patients with knee osteoarthritis are more likely to display a number of biomechanical characteristics. The causal relationship between specific biomechanical factors and the development of knee osteoarthritis could not be determined as no longitudinal studies were included. There is an urgent need for high quality, longitudinal studies to evaluate the impact of specific biomechanical factors on the development of knee osteoarthritis.

TRIAL REGISTRATION: (PROSPERO ID: CRD42015025092 ).

Original languageEnglish
JournalBMC Musculoskeletal Disorders
Volume19
Issue number1
Pages (from-to)273
ISSN1471-2474
DOIs
Publication statusPublished - 28 Jul 2018

ID: 56130364