Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia

Beakal Zinab; Rahma Ali; Bikila S Megersa; Tefera Belachew; Elias Kedir; Tsinuel Girma; Alemseged Abdisa; Melkamu Berhane; Bitiya Admasu; Henrik Friis; Mubarek Abera; Mette F Olsen; Gregers S Andersen; Jonathan Ck Wells; Suzanne Filteau; Rasmus Wibaek; Dorothea Nitsch; Daniel Yilma

doi:10.1016/j.ajcnut.2023.09.014

Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia

Beakal Zinab^*, Rahma Ali, Bikila S Megersa, Tefera Belachew, Elias Kedir, Tsinuel Girma, Alemseged Abdisa, Melkamu Berhane, Bitiya Admasu, Henrik Friis, Mubarek Abera, Mette F Olsen, Gregers S Andersen, Jonathan Ck Wells, Suzanne Filteau, Rasmus Wibaek, Dorothea Nitsch, Daniel Yilma

^*Corresponding author for this work

Abstract

BACKGROUND: Risk of noncommunicable diseases accrues from fetal life, with early childhood growth having an important role in adult disease risk. There is a need to understand how early-life growth relates to kidney function and size.

OBJECTIVES: This study aimed to assess the association of linear growth velocities among children between 0 and 6 y with kidney function and size among children aged 10 y.

METHODS: The Ethiopian Anthropometric and Body Composition birth cohort recruited infants born at term to mothers living in Jimma with a birth weight of ≥1500 g and without congenital malformations. Participants were followed up with 13 measurements between birth and 6 y of age. The latest follow-up was at ages 7-12 y with measurement of serum cystatin C as a marker of kidney function and ultrasound assessment of kidney dimensions. Kidney volume was computed using an ellipsoid formula. Linear-spline multilevel modeling was used to compute linear growth velocities between 0 and 6 y. Multiple linear regression modeling was used to examine the associations of linear growth velocities in selected age periods with cystatin C and kidney size.

RESULTS: Data were captured from 355 children, at a mean age of 10 (range 7-12) y. The linear growth velocity was high between 0 and 3 mo and then decreased with age. There was no evidence of an association of growth velocity ≤24 mo with cystatin C at 10 y. Between 24 and 48 and 48 and 76 mo, serum cystatin C was higher by 2.3% [95% confidence interval (CI): 0.6, 4.2] and 2.1% (95% CI: 0.3, 4.0) for 1 SD higher linear growth velocity, respectively. We found a positive association between linear growth velocities at all intervals between 0 and 6 y and kidney volume.

CONCLUSIONS: Greater linear growth between 0 and 6 y of development was positively associated with kidney size, and greater growth velocity after 2 y was associated with higher serum cystatin C concentrations.

Original language	English
Journal	The American journal of clinical nutrition
Volume	118
Issue number	6
Pages (from-to)	1145-1152
Number of pages	8
ISSN	0002-9165
DOIs	https://doi.org/10.1016/j.ajcnut.2023.09.014
Publication status	Published - Dec 2023

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Zinab, B., Ali, R., Megersa, B. S., Belachew, T., Kedir, E., Girma, T., Abdisa, A., Berhane, M., Admasu, B., Friis, H., Abera, M., Olsen, M. F., Andersen, G. S., Wells, J. C., Filteau, S., Wibaek, R., Nitsch, D., & Yilma, D. (2023). Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia. The American journal of clinical nutrition, 118(6), 1145-1152. https://doi.org/10.1016/j.ajcnut.2023.09.014

Zinab, B, Ali, R, Megersa, BS, Belachew, T, Kedir, E, Girma, T, Abdisa, A, Berhane, M, Admasu, B, Friis, H, Abera, M, Olsen, MF, Andersen, GS, Wells, JC, Filteau, S, Wibaek, R, Nitsch, D & Yilma, D 2023, 'Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia', The American journal of clinical nutrition, vol. 118, no. 6, pp. 1145-1152. https://doi.org/10.1016/j.ajcnut.2023.09.014

@article{fb0e2920448d4cbdbc8d7ccfe16221a6,

title = "Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia",

abstract = "BACKGROUND: Risk of noncommunicable diseases accrues from fetal life, with early childhood growth having an important role in adult disease risk. There is a need to understand how early-life growth relates to kidney function and size.OBJECTIVES: This study aimed to assess the association of linear growth velocities among children between 0 and 6 y with kidney function and size among children aged 10 y.METHODS: The Ethiopian Anthropometric and Body Composition birth cohort recruited infants born at term to mothers living in Jimma with a birth weight of ≥1500 g and without congenital malformations. Participants were followed up with 13 measurements between birth and 6 y of age. The latest follow-up was at ages 7-12 y with measurement of serum cystatin C as a marker of kidney function and ultrasound assessment of kidney dimensions. Kidney volume was computed using an ellipsoid formula. Linear-spline multilevel modeling was used to compute linear growth velocities between 0 and 6 y. Multiple linear regression modeling was used to examine the associations of linear growth velocities in selected age periods with cystatin C and kidney size.RESULTS: Data were captured from 355 children, at a mean age of 10 (range 7-12) y. The linear growth velocity was high between 0 and 3 mo and then decreased with age. There was no evidence of an association of growth velocity ≤24 mo with cystatin C at 10 y. Between 24 and 48 and 48 and 76 mo, serum cystatin C was higher by 2.3% [95% confidence interval (CI): 0.6, 4.2] and 2.1% (95% CI: 0.3, 4.0) for 1 SD higher linear growth velocity, respectively. We found a positive association between linear growth velocities at all intervals between 0 and 6 y and kidney volume.CONCLUSIONS: Greater linear growth between 0 and 6 y of development was positively associated with kidney size, and greater growth velocity after 2 y was associated with higher serum cystatin C concentrations.",

author = "Beakal Zinab and Rahma Ali and Megersa, {Bikila S} and Tefera Belachew and Elias Kedir and Tsinuel Girma and Alemseged Abdisa and Melkamu Berhane and Bitiya Admasu and Henrik Friis and Mubarek Abera and Olsen, {Mette F} and Andersen, {Gregers S} and Wells, {Jonathan Ck} and Suzanne Filteau and Rasmus Wibaek and Dorothea Nitsch and Daniel Yilma",

year = "2023",

month = dec,

doi = "10.1016/j.ajcnut.2023.09.014",

language = "English",

volume = "118",

pages = "1145--1152",

journal = "The American journal of clinical nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "6",

}

TY - JOUR

T1 - Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years

T2 - a birth cohort study in Ethiopia

AU - Zinab, Beakal

AU - Ali, Rahma

AU - Megersa, Bikila S

AU - Belachew, Tefera

AU - Kedir, Elias

AU - Girma, Tsinuel

AU - Abdisa, Alemseged

AU - Berhane, Melkamu

AU - Admasu, Bitiya

AU - Friis, Henrik

AU - Abera, Mubarek

AU - Olsen, Mette F

AU - Andersen, Gregers S

AU - Wells, Jonathan Ck

AU - Filteau, Suzanne

AU - Wibaek, Rasmus

AU - Nitsch, Dorothea

AU - Yilma, Daniel

PY - 2023/12

Y1 - 2023/12

N2 - BACKGROUND: Risk of noncommunicable diseases accrues from fetal life, with early childhood growth having an important role in adult disease risk. There is a need to understand how early-life growth relates to kidney function and size.OBJECTIVES: This study aimed to assess the association of linear growth velocities among children between 0 and 6 y with kidney function and size among children aged 10 y.METHODS: The Ethiopian Anthropometric and Body Composition birth cohort recruited infants born at term to mothers living in Jimma with a birth weight of ≥1500 g and without congenital malformations. Participants were followed up with 13 measurements between birth and 6 y of age. The latest follow-up was at ages 7-12 y with measurement of serum cystatin C as a marker of kidney function and ultrasound assessment of kidney dimensions. Kidney volume was computed using an ellipsoid formula. Linear-spline multilevel modeling was used to compute linear growth velocities between 0 and 6 y. Multiple linear regression modeling was used to examine the associations of linear growth velocities in selected age periods with cystatin C and kidney size.RESULTS: Data were captured from 355 children, at a mean age of 10 (range 7-12) y. The linear growth velocity was high between 0 and 3 mo and then decreased with age. There was no evidence of an association of growth velocity ≤24 mo with cystatin C at 10 y. Between 24 and 48 and 48 and 76 mo, serum cystatin C was higher by 2.3% [95% confidence interval (CI): 0.6, 4.2] and 2.1% (95% CI: 0.3, 4.0) for 1 SD higher linear growth velocity, respectively. We found a positive association between linear growth velocities at all intervals between 0 and 6 y and kidney volume.CONCLUSIONS: Greater linear growth between 0 and 6 y of development was positively associated with kidney size, and greater growth velocity after 2 y was associated with higher serum cystatin C concentrations.

AB - BACKGROUND: Risk of noncommunicable diseases accrues from fetal life, with early childhood growth having an important role in adult disease risk. There is a need to understand how early-life growth relates to kidney function and size.OBJECTIVES: This study aimed to assess the association of linear growth velocities among children between 0 and 6 y with kidney function and size among children aged 10 y.METHODS: The Ethiopian Anthropometric and Body Composition birth cohort recruited infants born at term to mothers living in Jimma with a birth weight of ≥1500 g and without congenital malformations. Participants were followed up with 13 measurements between birth and 6 y of age. The latest follow-up was at ages 7-12 y with measurement of serum cystatin C as a marker of kidney function and ultrasound assessment of kidney dimensions. Kidney volume was computed using an ellipsoid formula. Linear-spline multilevel modeling was used to compute linear growth velocities between 0 and 6 y. Multiple linear regression modeling was used to examine the associations of linear growth velocities in selected age periods with cystatin C and kidney size.RESULTS: Data were captured from 355 children, at a mean age of 10 (range 7-12) y. The linear growth velocity was high between 0 and 3 mo and then decreased with age. There was no evidence of an association of growth velocity ≤24 mo with cystatin C at 10 y. Between 24 and 48 and 48 and 76 mo, serum cystatin C was higher by 2.3% [95% confidence interval (CI): 0.6, 4.2] and 2.1% (95% CI: 0.3, 4.0) for 1 SD higher linear growth velocity, respectively. We found a positive association between linear growth velocities at all intervals between 0 and 6 y and kidney volume.CONCLUSIONS: Greater linear growth between 0 and 6 y of development was positively associated with kidney size, and greater growth velocity after 2 y was associated with higher serum cystatin C concentrations.

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U2 - 10.1016/j.ajcnut.2023.09.014

DO - 10.1016/j.ajcnut.2023.09.014

M3 - Journal article

C2 - 37758061

SN - 0002-9165

VL - 118

SP - 1145

EP - 1152

JO - The American journal of clinical nutrition

JF - The American journal of clinical nutrition

IS - 6

ER -

Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia

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