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Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study

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Harvard

Ried-Larsen, M, Rasmussen, MG, Blond, K, Overvad, TF, Overvad, K, Steindorf, K, Katzke, V, Andersen, JLM, Petersen, KEN, Aune, D, Tsilidis, KK, Heath, AK, Papier, K, Panico, S, Masala, G, Pala, V, Weiderpass, E, Freisling, H, Bergmann, MM, Verschuren, WMM, Zamora-Ros, R, Colorado-Yohar, SM, Spijkerman, AMW, Schulze, MB, Ardanaz, EMA, Andersen, LB, Wareham, N, Brage, S & Grøntved, A 2021, 'Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study', JAMA Internal Medicine, vol. 181, no. 9, pp. 1196-1205. https://doi.org/10.1001/jamainternmed.2021.3836

APA

Ried-Larsen, M., Rasmussen, M. G., Blond, K., Overvad, T. F., Overvad, K., Steindorf, K., Katzke, V., Andersen, J. L. M., Petersen, K. E. N., Aune, D., Tsilidis, K. K., Heath, A. K., Papier, K., Panico, S., Masala, G., Pala, V., Weiderpass, E., Freisling, H., Bergmann, M. M., ... Grøntved, A. (2021). Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study. JAMA Internal Medicine, 181(9), 1196-1205. https://doi.org/10.1001/jamainternmed.2021.3836

CBE

Ried-Larsen M, Rasmussen MG, Blond K, Overvad TF, Overvad K, Steindorf K, Katzke V, Andersen JLM, Petersen KEN, Aune D, Tsilidis KK, Heath AK, Papier K, Panico S, Masala G, Pala V, Weiderpass E, Freisling H, Bergmann MM, Verschuren WMM, Zamora-Ros R, Colorado-Yohar SM, Spijkerman AMW, Schulze MB, Ardanaz EMA, Andersen LB, Wareham N, Brage S, Grøntved A. 2021. Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study. JAMA Internal Medicine. 181(9):1196-1205. https://doi.org/10.1001/jamainternmed.2021.3836

MLA

Vancouver

Author

Ried-Larsen, Mathias ; Rasmussen, Martin Gillies ; Blond, Kim ; Overvad, Thure F ; Overvad, Kim ; Steindorf, Karen ; Katzke, Verena ; Andersen, Julie L M ; Petersen, Kristina E N ; Aune, Dagfinn ; Tsilidis, Kostas K ; Heath, Alicia K ; Papier, Keren ; Panico, Salvatore ; Masala, Giovanna ; Pala, Valeria ; Weiderpass, Elisabete ; Freisling, Heinz ; Bergmann, Manuela M ; Verschuren, W M Monique ; Zamora-Ros, Raul ; Colorado-Yohar, Sandra M ; Spijkerman, Annemieke M W ; Schulze, Matthias B ; Ardanaz, Eva M A ; Andersen, Lars Bo ; Wareham, Nick ; Brage, Søren ; Grøntved, Anders. / Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes : The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study. In: JAMA Internal Medicine. 2021 ; Vol. 181, No. 9. pp. 1196-1205.

Bibtex

@article{fce37a5f9a164b91bc7f04cd4442bd8f,
title = "Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study",
abstract = "Importance: Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes.Objective: To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality.Design, Setting, and Participants: This prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020.Exposures: The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination.Main Outcomes and Measures: The primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors.Results: Of the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality.Conclusion and Relevance: In this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists.",
author = "Mathias Ried-Larsen and Rasmussen, {Martin Gillies} and Kim Blond and Overvad, {Thure F} and Kim Overvad and Karen Steindorf and Verena Katzke and Andersen, {Julie L M} and Petersen, {Kristina E N} and Dagfinn Aune and Tsilidis, {Kostas K} and Heath, {Alicia K} and Keren Papier and Salvatore Panico and Giovanna Masala and Valeria Pala and Elisabete Weiderpass and Heinz Freisling and Bergmann, {Manuela M} and Verschuren, {W M Monique} and Raul Zamora-Ros and Colorado-Yohar, {Sandra M} and Spijkerman, {Annemieke M W} and Schulze, {Matthias B} and Ardanaz, {Eva M A} and Andersen, {Lars Bo} and Nick Wareham and S{\o}ren Brage and Anders Gr{\o}ntved",
year = "2021",
month = sep,
day = "1",
doi = "10.1001/jamainternmed.2021.3836",
language = "English",
volume = "181",
pages = "1196--1205",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "9",

}

RIS

TY - JOUR

T1 - Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes

T2 - The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study

AU - Ried-Larsen, Mathias

AU - Rasmussen, Martin Gillies

AU - Blond, Kim

AU - Overvad, Thure F

AU - Overvad, Kim

AU - Steindorf, Karen

AU - Katzke, Verena

AU - Andersen, Julie L M

AU - Petersen, Kristina E N

AU - Aune, Dagfinn

AU - Tsilidis, Kostas K

AU - Heath, Alicia K

AU - Papier, Keren

AU - Panico, Salvatore

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Weiderpass, Elisabete

AU - Freisling, Heinz

AU - Bergmann, Manuela M

AU - Verschuren, W M Monique

AU - Zamora-Ros, Raul

AU - Colorado-Yohar, Sandra M

AU - Spijkerman, Annemieke M W

AU - Schulze, Matthias B

AU - Ardanaz, Eva M A

AU - Andersen, Lars Bo

AU - Wareham, Nick

AU - Brage, Søren

AU - Grøntved, Anders

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Importance: Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes.Objective: To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality.Design, Setting, and Participants: This prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020.Exposures: The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination.Main Outcomes and Measures: The primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors.Results: Of the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality.Conclusion and Relevance: In this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists.

AB - Importance: Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes.Objective: To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality.Design, Setting, and Participants: This prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020.Exposures: The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination.Main Outcomes and Measures: The primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors.Results: Of the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality.Conclusion and Relevance: In this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists.

UR - http://www.scopus.com/inward/record.url?scp=85110867183&partnerID=8YFLogxK

U2 - 10.1001/jamainternmed.2021.3836

DO - 10.1001/jamainternmed.2021.3836

M3 - Journal article

C2 - 34279548

VL - 181

SP - 1196

EP - 1205

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 9

ER -

ID: 67383195