Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Case report a novel KERA mutation associated with cornea plana and its predicted effect on protein function

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Impact of PTBP1 rs11085226 on glucose-stimulated insulin release in adult Danes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Polygenic predisposition to breast cancer and the risk of coronary artery disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reappraisal of variants previously linked with sudden infant death syndrome: results from three population-based cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Clinical implications of electrocardiographic bundle branch block in primary care

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Cohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial fibrillation (AF). In this study, we hypothesized that single nucleotide polymorphisms (SNP) previously associated with AF may be associated with the risk of VF caused by first ST-segment elevation myocardial infarction (STEMI).

METHODS: We investigated association of 24 AF-associated SNPs with VF in the prospectively assembled case-control study among first STEMI-patients of Danish ancestry.

RESULTS: We included 257 cases (STEMI with VF) and 537 controls (STEMI without VF). The median age at index infarction was 60 years for the cases and 61 years for the controls (p = 0.100). Compared to the control group, the case group was more likely to be male (86% vs. 75%, p = 0.001), have a history of AF (7% vs. 2%, p = 0.006) or hypercholesterolemia (39% vs. 31%, p = 0.023), and a family history of sudden death (40% vs. 25%, p < 0.001). All 24 selected SNPs have previously been associated with AF. None of the 24 SNPs were associated with the risk of VF after adjustment for age and sex under additive genetic model of inheritance in the logistic regression model.

CONCLUSION: In this study, we found that the 24 AF-associated SNPs may not be involved in increasing the risk of VF. Larger VF cohorts and use of new next generation sequencing and epigenetic may in future identify additional AF and VF risk loci and improve our understanding of genetic pathways behind the two arrhythmias.

Original languageEnglish
JournalBMC Medical Genetics
Volume18
Issue number1
Pages (from-to)138
DOIs
Publication statusPublished - 21 Nov 2017

    Research areas

  • Journal Article

ID: 52050391